Study of hydroxyapatite and TiO2 thin films surface functionalized with bisphosphonates

• Grant number: 19/13100-0
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate (Direct)
• Start date: August 19, 2019
• End date: August 18, 2020
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Paulo Noronha Lisboa Filho
• Grantee: Leonardo Francisco Gonçalves Dias
• Supervisor: Paul-Ludwig Michael Noeske
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
• Institution abroad: Fraunhofer-Gesellschaft, Germany
• Associated to the scholarship: 18/07520-3 - Immobilization of bisphosphonates on nanostructured surface films of TiO2 and hydroxyapatite, BP.DD

Abstract

Metallic titanium and its alloys are widely used as implants in the biomedical industry. Biocompatibility questions of the implants still remain an open problem, even with a large use, failure of implants occurs, different strategies can be used to solve theses problems, surface modification is a promisor strategy. The implant surface can be modify using titanium dioxide, hydroxyapatite and others materials, forming a thin film, this film can be functionalized using peptides, proteins, small organic molecules. In this work commercial pure titanium surfaces will be modified with titanium oxide and hydroxyapatite thin films; the films will be functionalized using bisphosphonates and octadecylphosphonate, these modifications have the scope of increase the biocompatibility of implants. The samples will be analized using different surface thecniques such as XPS, AFM, ToF-SIM and others to undestand the interactions between the films, bisphosphonates and octadecylphosphonate. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GONCALVES DIAS, LEONARDO FRANCISCO; STAMBOROSKI, STEPHANI; NOESKE, MICHAEL; SALZ, DIRK; RISCHKA, KLAUS; PEREIRA, RENATA; MAINARDI, MARIA DO CARMO; CARDOSO, MARINA HONORATO; WIESING, MARTIN; BRONZE-UHLE, ERIKA SOARES; et al. New details of assembling bioactive films from dispersions of amphiphilic molecules on titania surfaces. RSC ADVANCES, v. 10, n. 65, p. 39854-39869, NOV 1 2020. (18/07520-3, 19/13100-0)

DIAS, LEONARDO F. G.; RHEINHEIMER, JOAO P. C.; GOMES, ORISSON P.; NOESKE, MICHAEL; STAMBOROSKI, STEPHANI; BRONZE-UHLE, ERIKA S.; MAINARDI, MARIA C.; CAVALCANTI, WELCHY L.; NETO, AUGUSTO B.; LISBOA-FILHO, PAULO N.. Bisphosphonates on Smooth TiO2: Modeling and Characterization. CHEMISTRYSELECT, v. 7, n. 19, p. 9-pg., 2022-04-20. (18/07520-3, 19/13100-0, 19/09431-0)