Iron and cardiometabolic risk factors in individuals living in the city of São Paulo: investigating the associations of the genetic susceptibility to type 2 diabetes, obesity and cardiovascular diseases

• Grant number: 19/05685-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2019
• End date: June 30, 2022
• Field of knowledge: Health Sciences - Nutrition - Nutritional Analysis of Population
• Principal Investigator: Regina Mara Fisberg
• Grantee: Cristiane Hermes Sales
• Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 17/05125-7 - Lifestyle, biochemical and genetic markers as cardiometabolic risk factors: Health Survey in São Paulo City, AP.TEM

Abstract

The purpose of this post-doctoral fellowship is to investigate the relationship between food consumption and iron status with cardio-metabolic risk factors in individuals living in the city of São Paulo, Brazil. This will consider genetic factors associated to the susceptibility of chronic non-communicable diseases, i.e., type 2 diabetes, obesity, and cardiovascular diseases. It will be evaluated 864 individuals with e12yo regarding their dietary iron intake (total, heme and non-heme iron), iron status, lipid and glycose control, inflammatory biomarkers, blood pressure, and presence of genetic markers of single nucleotide polymorphism markers that indicate the susceptibility to develop type 2 diabetes, obesity, and cardiovascular diseases. Multiple regressions models adjusted for several confounding and control variables will be used to identify the association between iron (heme, non-heme, and total) and iron status with the biomarkers.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SALES, CRISTIANE HERMES; ROGERO, MARCELO MACEDO; SARTI, FLAVIA MORI; FISBERG, REGINA MARA. Prevalence and Factors Associated with Iron Deficiency and Anemia among Residents of Urban Areas of Sao Paulo, Brazil. NUTRIENTS, v. 13, n. 6, JUN 2021. (19/05685-8, 17/05125-7, 12/22113-9)

SALES, CRISTIANE HERMES; FONTANELLI, MARIANE DE MELLO; ROGERO, MARCELO MACEDO; SARTI, FLAVIA MORI; FISBERG, REGINA MARA. Dietary inadequacies overestimate the blood deficiencies of magnesium, zinc, and vitamins A, C, E, and D among residents of Sao Paulo. CLINICAL NUTRITION ESPEN, v. 53, p. 10-pg., 2023-01-17. (17/05125-7, 12/22113-9, 19/05685-8)