Analysis and classification of human microbiomes: detection of bioindicators and optimization through machine learning

• Grant number: 19/03396-9
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: June 01, 2019
• End date: January 14, 2024
• Field of knowledge: Physical Sciences and Mathematics - Computer Science - Computing Methodologies and Techniques
• Principal Investigator: André Carlos Ponce de Leon Ferreira de Carvalho
• Grantee: Jonas Coelho Kasmanas
• Host Institution: Instituto de Ciências Matemáticas e de Computação (ICMC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated research grant: 13/07375-0 - CeMEAI - Center for Mathematical Sciences Applied to Industry, AP.CEPID
• Associated scholarship(s): 22/03534-5 - Genome centric analysis of the human microbiome: detection of bioindicators and optimization through machine learning, BE.EP.DD

Abstract

The microbial community that inhabits various regions of the human body, whether skin, gut, esophagus, mouth, vagina and others, is called the human microbiome. These communities participate in essential processes to human health - such as digestion, nutrient absorption, detoxification, protection against pathogens, and regulation of the immune system. Thus, changes in the microbiome can cause various diseases. Therefore, the analysis of the human microbiome can help the early diagnosis of several disorders. Among the diseases that have already been correlated with the human microbiome, we can mention infections, colorectal and Esophageal Cancer, Cirrhosis and even Autism and Depression. For this reason, microbiome studies have developed widely, generating large amounts of information about these communities, and, thus, creating the Human Microbiome Big Data (HM Big Data). At the same time, Machine Learning (ML) - a data analysis strategy in which algorithms receive a set of treated data and are able to extract models, patterns and knowledge of these data - has been shown to be an efficient way of dealing with large amounts of information, such as HM Big Data. Using several of these approaches, this project will collect and select metagenomes from human microbiomes available in public databases. From these metagenomes, I will reconstruct Metagenome Assembled Genomes (MAGs) using several Bioinformatics pipelines. Then, this data will be used to create machine learning models capable of differentiating health and disease. Finally, these models must be optimized through Automatic Machine Learning (AutoML) techniques and analyzed with the intention of discovering new bioindicators of human diseases. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KASMANAS, JONAS COELHO; BARTHOLOMAEUS, ALEXANDER; CORREA, FELIPE BORIM; TAL, TAMARA; JEHMLICH, NICO; HERBERTH, GUNDA; VON BERGEN, MARTIN; STADLER, PETER F.; DE LEON FERREIRA DE CARVALHO, ANDRE CARLOS PONCE; DA ROCHA, ULISSES NUNES. HumanMetagenomeDB: a public repository of curated and standardized metadata for human metagenomes. Nucleic Acids Research, v. 49, n. D1, p. D743-D750, JAN 8 2021. (13/07375-0, 19/03396-9)

LIU, BIN; STRAEUBER, HEIKE; SARAIVA, JOAO; HARMS, HAUKE; SILVA, SANDRA GODINHO; KASMANAS, JONAS COELHO; KLEINSTEUBER, SABINE; DA ROCHA, ULISSES NUNES. Machine learning-assisted identification of bioindicators predicts medium-chain carboxylate production performance of an anaerobic mixed culture. MICROBIOME, v. 10, n. 1, p. 21-pg., 2022-03-25. (19/03396-9)