Hemocompatible materials with surfaces modified by zwitterionic molecules

• Grant number: 19/09431-0
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: July 01, 2019
• End date: December 31, 2023
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Paulo Noronha Lisboa Filho
• Grantee: Orisson Ponce Gomes
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
• Associated research grant: 13/07296-2 - CDMF - Center for the Development of Functional Materials, AP.CEPID
• Associated scholarship(s): 21/10891-6 - Facile and versatile immobilization method for Rhodamine-based dyes as ion chemosensor for surface-enhanced Resonance Raman spectroscopy, BE.EP.DR

Abstract

Exposure of materials that come in contact with blood can result in numerous interactions. Interactions between the surface covering these materials and blood elements, such as plasma protein adsorption, blood cell activation, platelet adhesion and thrombotic reactions, can trigger severe blood reactions, causing an increase in the failure rate of the device and even in mortality and morbidity rate of the patients. Although strategies to minimize the blood immune response with the coating surface of these biomaterials are being developed, many of the specific factors that trigger this immune response are still unknown. This proposal is linked to the health division of the Center for Research and Development of Functional Materials (CDFM/CEPID/FAPESP 2013/07296-2) and it and has as a general objective to develop a new generation of coatings with zwitterionic molecules for biomedical devices that come into contact with blood in order to obtain hemocompatible and antifouling surfaces. It is intended, therefore, to obtain devices that suppress possibilities of non-specific adsorption of proteins, cell adhesion or other undesired interactions that may negatively influence their performance. As specific objectives, the present study aims to investigate the behavior of zwitterionic molecules in the presence of water molecules and blood components from theoretical-experimental approaches.

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GALINDO, L. A.; GOMES, O. P.; GRAEFF, C. F. O.; BATAGIN-NETO, A.. Optical and structural properties of cyanine dyes via electronic structure calculations. COMPUTATIONAL AND THEORETICAL CHEMISTRY, v. 1199, MAY 2021. (19/09431-0, 12/03116-7)

GOMES, ORISSON P.; RHEINHEIMER, JOAO P. C.; DIAS, LEONARDO F. G.; BATAGIN-NETO, AUGUSTO; LISBOA-FILHO, PAULO N.. Revisiting the hydroxylation phenomenon of SiO2: a study through "hard-hard" and "soft-soft" interactions. Journal of Molecular Modeling, v. 28, n. 5, p. 10-pg., 2022-05-01. (19/09431-0, 13/07296-2)

DIAS, LEONARDO F. G.; RHEINHEIMER, JOAO P. C.; GOMES, ORISSON P.; NOESKE, MICHAEL; STAMBOROSKI, STEPHANI; BRONZE-UHLE, ERIKA S.; MAINARDI, MARIA C.; CAVALCANTI, WELCHY L.; NETO, AUGUSTO B.; LISBOA-FILHO, PAULO N.. Bisphosphonates on Smooth TiO2: Modeling and Characterization. CHEMISTRYSELECT, v. 7, n. 19, p. 9-pg., 2022-04-20. (18/07520-3, 19/13100-0, 19/09431-0)

BARBOZA, BRUNO HORI; GOMES, ORISSON PONCE; BATAGIN-NETO, AUGUSTO. Polythiophene derivatives as chemical sensors: a DFT study on the influence of side groups. Journal of Molecular Modeling, v. 27, n. 1, JAN 7 2021. (19/09431-0)

GOMES, O. P.; BATAGIN-NETO, A.; LISBOA-FILHO, P. N.. The evaluation of anchoring processes and chemical stability of zwitterionic molecules via local reactivity indexes. COMPUTATIONAL MATERIALS SCIENCE, v. 193, p. 9-pg., 2021-03-14. (13/07296-2, 19/09431-0)