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Hemocompatible materials with surfaces modified by zwitterionic molecules

Grant number: 19/09431-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2019
Effective date (End): March 31, 2023
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Paulo Noronha Lisboa Filho
Grantee:Orisson Ponce Gomes
Home Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil
Associated research grant:13/07296-2 - CDMF - Center for the Development of Functional Materials, AP.CEPID

Abstract

Exposure of materials that come in contact with blood can result in numerous interactions. Interactions between the surface covering these materials and blood elements, such as plasma protein adsorption, blood cell activation, platelet adhesion and thrombotic reactions, can trigger severe blood reactions, causing an increase in the failure rate of the device and even in mortality and morbidity rate of the patients. Although strategies to minimize the blood immune response with the coating surface of these biomaterials are being developed, many of the specific factors that trigger this immune response are still unknown. This proposal is linked to the health division of the Center for Research and Development of Functional Materials (CDFM/CEPID/FAPESP 2013/07296-2) and it and has as a general objective to develop a new generation of coatings with zwitterionic molecules for biomedical devices that come into contact with blood in order to obtain hemocompatible and antifouling surfaces. It is intended, therefore, to obtain devices that suppress possibilities of non-specific adsorption of proteins, cell adhesion or other undesired interactions that may negatively influence their performance. As specific objectives, the present study aims to investigate the behavior of zwitterionic molecules in the presence of water molecules and blood components from theoretical-experimental approaches.