Genome wide selection in sugarcane using machine learning and complex networks for economically important traits

• Grant number: 19/03232-6
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: August 01, 2019
• End date: May 31, 2024
• Field of knowledge: Biological Sciences - Genetics - Plant Genetics
• Principal Investigator: Anete Pereira de Souza
• Grantee: Alexandre Hild Aono
• Host Institution: Centro de Biologia Molecular e Engenharia Genética (CBMEG). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 19/26858-8 - Simulation of plant complex trait architectures using deep neural networks, BE.EP.DD

Abstract

The use of molecular markers SNPs (Single Nucleotide Polymorphisms), although made a major contribution to genetic improvement programs, has limited application in the case of sugarcane, a species with high genomic complexity. Due to the lack of biocomputational tools compatible with the uniqueness of the species, specific methodologies have to be used. With immeasurable importance to the sectors of biofuels and sugar manufacturing, the improvement of the species and the cultivars with characters of economic importance represent a major contribution to the world economy. Due to the polygenic nature of quantitative phenotypic characteristics and the consequent complexity of application of methods for genotype-phenotype association, genomic selection methodologies have been shown to be an alternative to traditional approaches for marker-assisted selection. The present work proposes an innovative approach for realization of selection in cane. Using an array of putative SNPs identified with the use of sequencing genotyping data and software adapted to polyploidy and aneuploidy of the species, an association modeling will be used between these markers using complex networks. By means of detection methods of communities in the built network, it is intended to carry out data imputation, dimensionality and identification of SNPs with related biological categories. For constructionof the selection model will be used machine learning techniques as models nonlinear, constructed to capture the specificity of the cane genome. (AU)

Scientific publications

(21)

(The scientific publications listed on this page originate from the Web of Science or SciELO databases. Their authors have cited FAPESP grant or fellowship project numbers awarded to Principal Investigators or Fellowship Recipients, whether or not they are among the authors. This information is collected automatically and retrieved directly from those bibliometric databases.)

GONZAGA PIMENTA, RICARDO JOSE; AONO, ALEXANDRE HILD; VILLAVICENCIO BURBANO, ROBERTO CARLOS; COUTINHO, ALISSON ESDRAS; DA SILVA, CARLA CRISTINA; ANTONIO DOS ANJOS, IVAN; PERECIN, DILERMANDO; DE ANDRADE LANDELL, MARCOS GUIMARAES; GONCALVES, MARCOS CESAR; PINTO, LUCIANA ROSSINI; et al. Genome-wide approaches for the identification of markers and genes associated with sugarcane yellow leaf virus resistance. SCIENTIFIC REPORTS, v. 11, n. 1, AUG 3 2021. (19/03232-6, 15/24346-9, 18/18588-8, 19/21682-9)

AONO, ALEXANDRE HILD; ULBRICHT FERREIRA, REBECCA CAROLINE; LIMA MORAES, ALINE DA COSTA; DE CASTRO LARA, LETICIA APARECIDA; GONZAGA PIMENTA, RICARDO JOSE; COSTA, ESTELA ARAUJO; PINTO, LUCIANA ROSSINI; DE ANDRADE LANDELL, MARCOS GUIMARAES; SANTOS, MATEUS FIGUEIREDO; JANK, LIANA; et al. A joint learning approach for genomic prediction in polyploid grasses. SCIENTIFIC REPORTS, v. 12, n. 1, p. 17-pg., 2022-07-21. (19/26858-8, 18/19219-6, 19/21682-9, 19/03232-6)

MARTINS, FELIPE BITENCOURT; AONO, ALEXANDRE HILD; MORAES, ALINE DA COSTA LIMA; FERREIRA, REBECCA CAROLINE ULBRICHT; VILELA, MARIANE DE MENDONCA; PESSOA-FILHO, MARCO; RODRIGUES-MOTTA, MARIANA; SIMEAO, ROSANGELA MARIA; SOUZA, ANETE PEREIRA DE. Genome-wide family prediction unveils molecular mechanisms underlying the regulation of agronomic traits in Urochloa ruziziensis. FRONTIERS IN PLANT SCIENCE, v. 14, p. 22-pg., 2023-12-12. (19/03232-6, 18/19219-6)

PIMENTA, RICARDO JOSE GONZAGA; AONO, ALEXANDRE HILD; BURBANO, ROBERTO CARLOS VILLAVICENCIO; SILVA, MARCEL FERNANDO DA; ANJOS, IVAN ANTONIO DOS; LANDELL, MARCOS GUIMARAES DE ANDRADE; GONCALVES, MARCOS CESAR; PINTO, LUCIANA ROSSINI; SOUZA, ANETE PEREIRA DE. Multiomic investigation of Sugarcane mosaic virus resistance in sugarcane. CROP JOURNAL, v. 11, n. 6, p. 11-pg., 2023-12-01. (19/03232-6, 19/21682-9, 18/18588-8)

MIRANDA, MELISSA CRISTINA DE CARVALHO; AONO, ALEXANDRE HILD; PINHEIRO, JOSE BALDIN. A novel image-based approach for soybean seed phenotyping using machine learning techniques. CROP SCIENCE, v. 63, n. 5, p. 20-pg., 2023-07-02. (19/03232-6)

FERREIRA FILHO, JAIRE A.; ROSOLEN, RAFAELA R.; ALMEIDA, DEBORAH A.; DE AZEVEDO, PAULO HENRIQUE C.; MOTTA, MARIA LORENZA L.; AONO, ALEXANDRE H.; DOS SANTOS, CLELTON A.; HORTA, MARIA AUGUSTA C.; DE SOUZA, ANETE P.. Trends in biological data integration for the selection of enzymes and transcription factors related to cellulose and hemicellulose degradation in fungi. 3 BIOTECH, v. 11, n. 11, NOV 2021. (15/09202-0, 19/03232-6, 20/13420-1, 18/19660-4, 20/10536-9)

ROSOLEN, RAFAELA ROSSI; AONO, ALEXANDRE HILD; ALMEIDA, DEBORAH AIRES; FERREIRA FILHO, JAIRE ALVES; HORTA, MARIA AUGUSTA CRIVELENTE; DE SOUZA, ANETE PEREIRA. Network Analysis Reveals Different Cellulose Degradation Strategies Across Trichoderma harzianum Strains Associated With XYR1 and CRE1. FRONTIERS IN GENETICS, v. 13, p. 19-pg., 2022-02-24. (18/19660-4, 20/13420-1, 15/09202-0, 19/03232-6)

BEGNAMI, ISABELA DOS SANTOS; AONO, ALEXANDRE HILD; GRACIANO, DIEGO DA SILVA; CARMELLO-GUERREIRO, SANDRA MARIA; FERREIRA, REBECCA CAROLINE ULBRICHT; MALAGO JR, WILSON; MATTA, FREDERICO DE PINA; GUSMAO, MARCOS RAFAEL; DE SOUZA, ANETE PEREIRA; VIGNA, BIANCA BACCILI ZANOTTO. Elucidating Molecular Responses to Spittlebug Attack in Paspalum regnellii. PLANT MOLECULAR BIOLOGY REPORTER, v. N/A, p. 17-pg., 2024-08-03. (19/03232-6, 18/19219-6)

MARTINS, FELIPE BITENCOURT; MORAES, ALINE COSTA LIMA; AONO, ALEXANDRE HILD; FERREIRA, REBECCA CAROLINE ULBRICHT; CHIARI, LUCIMARA; SIMEAO, ROSANGELA MARIA; BARRIOS, SANZIO CARVALHO LIMA; SANTOS, MATEUS FIGUEIREDO; JANK, LIANA; DO VALLE, CACILDA BORGES; et al. Semi-Automated SNP-Based Approach for Contaminant Identification in Biparental Polyploid Populations of Tropical Forage Grasse. FRONTIERS IN PLANT SCIENCE, v. 12, OCT 22 2021. (18/19219-6, 19/03232-6)

AONO, ALEXANDRE HILD; GONZAGA PIMENTA, RICARDO JOSE; BASSO GARCIA, ANA LETYCIA; CORRER, FERNANDO HENRIQUE; HOSAKA, GUILHERME KENICHI; CARRASCO, MARISHANI MARIN; CARDOSO-SILVA, CLAUDIO BENICIO; MANCINI, MELINA CRISTINA; SFORCA, DANILO AUGUSTO; DOS SANTOS, LUCAS BORGES; et al. The Wild Sugarcane and Sorghum Kinomes: Insights Into Expansion, Diversification, and Expression Patterns. FRONTIERS IN PLANT SCIENCE, v. 12, JUL 7 2021. (14/11482-9, 18/18588-8, 19/03232-6, 15/22993-7, 15/16399-5, 08/52197-4, 19/21682-9, 05/55258-6, 19/19340-2)

FRANCISCO, FELIPE ROBERTO; AONO, ALEXANDRE HILD; DA SILVA, CARLA CRISTINA; GONCALVES, PAULO S.; SCALOPPI JUNIOR, ERIVALDO J. J.; LE GUEN, VINCENT; FRITSCHE-NETO, ROBERTO; SOUZA, LIVIA MOURA; SOUZA, ANETE PEREIRA DE. Unravelling Rubber Tree Growth by Integrating GWAS and Biological Network-Based Approaches. FRONTIERS IN PLANT SCIENCE, v. 12, DEC 21 2021. (18/18985-7, 19/03232-6)

DAMBROZ, CAROLINE MARCELA DA SILVA; AONO, ALEXANDRE HILD; SILVA, EDSON MARIO DE ANDRADE; PEREIRA, WELISON ANDRADE. Genome-wide analysis and characterization of the LRR-RLK gene family provides insights into anthracnose resistance in common bean. SCIENTIFIC REPORTS, v. 13, n. 1, p. 15-pg., 2023-08-18. (19/03232-6)

AONO, ALEXANDRE HILD; COSTA, ESTELA ARAUJO; SILVA RODY, HUGO VIANNA; NAGAI, JAMES SHINITI; GONZAGA PIMENTA, RICARDO JOSE; MANCINI, MELINA CRISTINA; CAMILO DOS SANTOS, FERNANDA RAQUEL; PINTO, LUCIANA ROSSINI; DE ANDRADE LANDELL, MARCOS GUIMARAES; DE SOUZA, ANETE PEREIRA; et al. Machine learning approaches reveal genomic regions associated with sugarcane brown rust resistance. SCIENTIFIC REPORTS, v. 10, n. 1, NOV 18 2020. (18/18588-8, 05/55258-6, 14/11482-9, 08/52197-4, 19/03232-6)

CARDOSO-SILVA, CLAUDIO BENICIO; AONO, ALEXANDRE HILD; MANCINI, MELINA CRISTINA; SFORCA, DANILO AUGUSTO; DA SILVA, CARLA CRISTINA; PINTO, LUCIANA ROSSINI; ADAMS, KEITH L.; DE SOUZA, ANETE PEREIRA. Taxonomically Restricted Genes Are Associated With Responses to Biotic and Abiotic Stresses in Sugarcane (Saccharum spp.). FRONTIERS IN PLANT SCIENCE, v. 13, p. 13-pg., 2022-06-30. (14/11482-9, 15/16399-5, 19/03232-6, 15/24346-9, 17/26781-0, 08/52197-4)

AONO, ALEXANDRE HILD; BAJAY, STEPHANIE KARENINA; FRANCISCO, FELIPE ROBERTO; DE SOUZA, ANETE PEREIRA. Genome-wide association reveals novel insights into the molecular mechanisms regulating stem volume in Pinus taeda. Tree Genetics & Genomes, v. 21, n. 3, p. 23-pg., 2025-06-01. (19/13452-3, 19/03232-6, 18/18985-7)

AONO, ALEXANDRE HILD; PIMENTA, RICARDO JOSE GONZAGA; DAMBROZ, CAROLINE MARCELA DA SILVA; COSTA, FRANCISCO CLEILSON LOPES; KUROSHU, REGINALDO MASSANOBU; DE SOUZA, ANETE PEREIRA; PEREIRA, WELISON ANDRADE. Genome-wide characterization of the common bean kinome: Catalog and insights into expression patterns and genetic organization. Gene, v. 855, p. 12-pg., 2022-12-24. (19/21682-9, 19/03232-6)

DOS SANTOS, LUCAS BORGES; AONO, ALEXANDRE HILD; FRANCISCO, FELIPE ROBERTO; DA SILVA, CARLA CRISTINA; SOUZA, LIVIA MOURA; DE SOUZA, ANETE PEREIRA. The rubber tree kinome: Genome-wide characterization and insights into coexpression patterns associated with abiotic stress responses. FRONTIERS IN PLANT SCIENCE, v. 14, p. 14-pg., 2023-02-07. (19/19340-2, 18/18985-7, 19/03232-6)

AONO, ALEXANDRE HILD; FRANCISCO, FELIPE ROBERTO; SOUZA, LIVIA MOURA; GONCALVES, PAULO DE SOUZA; SCALOPPI JUNIOR, ERIVALDO J.; LE GUEN, VINCENT; FRITSCHE-NETO, ROBERTO; GORJANC, GREGOR; QUILES, MARCOS GONCALVES; DE SOUZA, ANETE PEREIRA. A divide-and-conquer approach for genomic prediction in rubber tree using machine learning. SCIENTIFIC REPORTS, v. 12, n. 1, p. 14-pg., 2022-10-26. (19/26858-8, 18/18985-7, 19/03232-6)

NIEDERAUER, GUILHERME FRANCIO; DE OLIVEIRA, GEOVANI LUCIANO; AONO, ALEXANDRE HILD; DA SILVA GRACIANO, DIEGO; CARMELLO-GUERREIRO, SANDRA MARIA; MOURA, MARA FERNANDES; DE SOUZA, ANETE PEREIRA. Uncovering the molecular mechanisms of russet skin formation in Niagara grapevine (Vitis vinifera x Vitis labrusca). SCIENTIFIC REPORTS, v. 14, n. 1, p. 15-pg., 2024-03-19. (19/03232-6, 20/12938-7)

MARTINS, MONICA LETICIA TURIBIO; SFORCA, DANILO AUGUSTO; DOS SANTOS, LUIS PAULO; PIMENTA, RICARDO JOSE GONZAGA; MANCINI, MELINA CRISTINA; AONO, ALEXANDRE HILD; CARDOSO-SILVA, CLAUDIO BENICIO; VAUTRIN, SONIA; BELLEC, ARNAUD; DOS SANTOS, RENATO VICENTINI; et al. Identifying candidate genes for sugar accumulation in sugarcane: an integrative approach. BMC Genomics, v. 25, n. 1, p. 18-pg., 2024-12-18. (19/03232-6, 17/18225-0, 19/21682-9)

DA SILVA DAMBROZ, CAROLINE MARCELA; AONO, ALEXANDRE HILD; COSTA, LARISSA CARVALHO; NOVAES, EVANDRO; PEREIRA, WELISON ANDRADE. Comparative transcriptome analysis provides new insights into the response of common bean to infection by race 65 of Colletotrichum lindemuthianum. PLoS One, v. 20, n. 10, p. 21-pg., 2025-10-17. (19/03232-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

AONO, Alexandre Hild. Innovations in omics analyses of sugarcane: unraveling traits of economic importance. 2024. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia Campinas, SP.