Role of TLR2 and TLR9-dependent signalling in epithelial or dendritic cells in lung inflammation during allergen reexposure and pneumococcal infection

• Grant number: 19/09881-6
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2019
• End date: January 31, 2023
• Field of knowledge: Biological Sciences - Immunology - Cellular Immunology
• Principal Investigator: Vânia Luiza Deperon Bonato
• Grantee: Thais Fernanda de Campos Fraga da Silva
• Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 17/21629-5 - Strategies to study pulmonary inflammation during comorbidities, AP.TEM

Abstract

Concerning asthma, the post-doctoral project entitled "Role of TLR2 and TLR9-dependent signalling in epithelial or dendritic cells in lung inflammation during allergen reexposureand pneumococcal infection" aims to determine the contribution of TLR2 and/or TLR9-dependent signalling in epithelial and/or myeloid cells for Th17 profile induction and neutrophil migration in asthma and pneumonia comorbidity.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FUMAGALLI, MARCILIO JORGE; CASTRO-JORGE, LUIZA ANTUNES; FRAGA-SILVA, THAIS FERNANDA DE CAMPOS; DE AZEVEDO, PATRICK ORESTES; CAPATO, CARLOS FABIANO; RATTIS, BRUNA AMANDA CRUZ; HOJO-SOUZA, NATALIA SATCHIKO; FLORIANO, VITOR GONCALVES; DE CASTRO, JULIA TEIXEIRA; RAMOS, SIMONE GUSMAO; et al. Protective Immunity against Gamma and Zeta Variants after Inactivated SARS-CoV-2 Virus Immunization. Viruses-Basel, v. 13, n. 12, DEC 2021. (19/26119-0, 20/05527-0, 18/09383-3, 19/09881-6, 19/11213-1)

FUZO, CARLOS A.; FRAGA-SILVA, THAIS F. C.; MARUYAMA, SANDRA R.; BASTOS, VICTOR A. F.; ROGERIO, LUANA A.; TAKAMIYA, NAYORE T.; DA SILVA-NETO, PEDRO V.; PIMENTEL, VINICIUS E.; TORO, DIANA M.; PEREZ, MALENA M.; et al. The turning point of COVID-19 severity is associated with a unique circulating neutrophil gene signature. IMMUNOLOGY, v. 169, n. 3, p. 21-pg., 2023-03-08. (15/00658-1, 21/04590-3, 20/08534-8, 20/05207-6, 19/09881-6, 14/07125-6, 20/05270-0, 17/16328-6)

MARTINS, NUBIA SABRINA; DE CAMPOS FRAGA-SILVA, THAIS FERNANDA; CORREA, GISELI FURLAN; BOKO, MEDETON MAHOUSSI MICHAEL; RAMALHO, LEANDRA NAIRA ZAMBELLI; RODRIGUES, DEBORA MUNHOZ; HORI, JULIANA ISSA; COSTA, DIEGO LUIS; BASTOS, JAIRO KENUPP; BONATO, VANIA LUIZA DEPERON. Artepillin C Reduces Allergic Airway Inflammation by Induction of Monocytic Myeloid-Derived Suppressor Cells. PHARMACEUTICS, v. 13, n. 11, NOV 2021. (19/09881-6, 19/23446-0, 19/18793-3, 17/04138-8)