Advanced search
Start date
Betweenand

Strategies to study pulmonary inflammation during comorbidities

Grant number: 17/21629-5
Support type:Research Projects - Thematic Grants
Duration: April 01, 2019 - March 31, 2024
Field of knowledge:Biological Sciences - Immunology - Cellular Immunology
Principal researcher:Vânia Luiza Deperon Bonato
Grantee:Vânia Luiza Deperon Bonato
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Pesquisadores principais:
Alexandra Ivo de Medeiros
Assoc. researchers:Ana Paula Moreira Serezani ; Armin Braun ; Carlos Henrique Cardoso Serezani ; Daniela Carlos Sartori ; Dario Simões Zamboni ; Elcio dos Santos Oliveira Vianna ; José Carlos Farias Alves Filho ; Leandra Náira Zambelli Ramalho ; Marcelo Dias Baruffi ; Marcos de Carvalho Borges ; Momtchilo Russo ; Rita de Cassia Aleixo Tostes Passaglia ; Valdes Roberto Bollela ; Vanessa Carregaro Pereira
Associated grant(s):20/05270-0 - Role of human airway epithelial cell death in the inflammation caused by 2019-nCoV and confirmation by trascriptional analysis of infected patients, AP.R
19/11213-1 - Multiusuary equipament in the grant 2017/21629-5, flow cytometry FACS melody 2-lasers, 6-colors (4-2) blue violet, AP.EMU
Associated scholarship(s):21/08262-0 - Technical training in laboratory animal maintenance, cell culture and flow cytometry, BP.TT
19/24681-3 - Interaction of type II alveolar epithelial cells infected by Mycobacterium tuberculosis with populations of infected or non-infected macrophage, BP.MS
19/09881-6 - Role of TLR2 and TLR9-dependent signalling in epithelial or dendritic cells in lung inflammation during allergen reexposure and pneumococcal infection, BP.PD

Abstract

Comorbidities are one of the factors related to the development of more severe forms of asthma and tuberculosis. Both diseases are immuno-mediated (immunopathologies), characterized by exacerbation of pulmonary inflammation, but triggered by different effector mechanisms. The Subprojects contained in this proposal have a clear objective: to determine mechanisms that exacerbate pulmonary inflammation, aiming at the identification of molecules or cells that may represent the search for immunological targets for the development of innovative therapies for the most severe forms of asthma and tuberculosis. For this we will use experimental models asthma and pneumonia caused by pneumococcus, obesity and tuberculosis, diabetes and tuberculosis, which are comorbidities associated with the immunopathology of both diseases. To complement and validate preclinical studies, trials with samples of patients with asthma or tuberculosis are also covered in this proposal. The second clearly defined objective is the training of human resources and the development of quality research with translational potential. In this way we seek the intellectual, ethical, scientific and critical training to obtain innovative and consistent results that can positively affect the diffusion of Brazilian science to the world. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
Articles published in other media outlets (0 total):
More itemsLess items
VEICULO: TITULO (DATA)
VEICULO: TITULO (DATA)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DE CAMPOS FRAGA-SILVA, THAIS FERNANDA; MARUYAMA, SANDRA REGINA; SORGI, CARLOS ARTERIO; DE SOUSA RUSSO, ELISA MARIA; MORAIS FERNANDES, ANA PAULA; DE BARROS CARDOSO, CRISTINA RIBEIRO; FACCIOLI, LUCIA HELENA; DIAS-BARUFFI, MARCELO; DEPERON BONATO, VANIA LUIZA. COVID-19: Integrating the Complexity of Systemic and Pulmonary Immunopathology to Identify Biomarkers for Different Outcomes. FRONTIERS IN IMMUNOLOGY, v. 11, JAN 29 2021. Web of Science Citations: 0.
RODRIGUES, TAMARA SILVA; ALVAREZ, ANNIE ROCIO PINEROS; GEMBRE, ANA FLAVIA; FORNI, MARIA FERNANDA PEREIRA DE ARAUJO DEMONTE; DE MELO, BRUNO MARCEL SILVA; ALVES FILHO, JOSE CARLOS FARIAS; CAMARA, NIELS OLSEN SARAIVA; BONATO, VANIA LUIZA DEPERON. Mycobacterium tuberculosis-infected alveolar epithelial cells modulate dendritic cell function through the HIF-1 alpha-NOS2 axis. Journal of Leukocyte Biology, JUN 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.