Development and physical-chemical characterization of nanostructured antibiotics

• Grant number: 19/09719-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2019
• End date: May 31, 2020
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Laura de Oliveira Nascimento
• Grantee: Ana Flávia Siqueira Vicente
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

Meningitis is the acute inflammation of the meninges, which can be caused by viruses, bacteria, fungi and parasites. When untreated, the main complications are deafness, epilepsy, cognitive deficit and ultimately death. Ceftriaxone, ampicillin and vancomycin antibiotics are the ones frequently used in the treatment of this disease. However, some of these antibiotics have adverse effects and short half-life. Thus, sustained-release pharmaceutical formulations may prolong the effect, decrease dose and, consequently, avoid undesired effects. Based on the exposed above, this project aims to nanostructure antibiotics for the future treatment of bacterial meningitis. For this purpose, it is proposed to develop formulations and perform the physical-chemical and kinetic characterization of in vitro drug release of these systems. This proposal is part of a more comprehensive project, which will make the biological evaluation of formulations optimized.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BERALDO-ARAUJO, VIVIANE LUCIA; SIQUEIRA VICENTE, ANA FLAVIA; LIMA, MARCELO VAN VLIET; UMERSKA, ANITA; SOUTO, ELIANA B.; TAJBER, LIDIA; OLIVEIRA-NASCIMENTO, LAURA. Levofloxacin in nanostructured lipid carriers: Preformulation and critical process parameters for a highly incorporated formulation. International Journal of Pharmaceutics, v. 626, p. 13-pg., 2022-10-15. (20/08059-8, 19/09719-4, 18/03666-3)