Cell cycle control in normal and malignant cells, new approach in cancer therapy.

• Grant number: 19/13039-9
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2019
• End date: June 30, 2023
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Hugo Aguirre Armelin
• Grantee: Rosangela Aparecida Wailemann Mansano
• Host Institution: Instituto Butantan. Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil
• Associated research grant: 13/07467-1 - CeTICS - Center of Toxins, Immune-Response and Cell Signaling, AP.CEPID

Abstract

TITLE: Cell cycle control in normal and malignant cells, new approach in cancer therapy.ABSTRACTThis project is focused on experimental proof of concept of the following hypothesis: malignant cells, but not normal cells, are killed by certain combinations of a mitogen plus an inhibitor targeting a specific stress pathway. This hypothesis was first proposed in a recent paper of our laboratory (Dias et al, Molecular Oncology, 2019). The project experimental approach involves analysis of a panel of tumor cell lines from humans and rodents in cell cultures ("in vitro") and in mice ("in vivo"). Rodent tumor cells will be inoculated in immune-competent Balb/c mice, whereas human tumor cells will be inoculated in immune-deficient Balb-Nude mice.