Binary metal oxides in biosensors for early diagnosis of cancer

• Grant number: 19/10693-0
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2019
• End date: February 28, 2021
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Osvaldo Novais de Oliveira Junior
• Grantee: Beatriz Montilha Tirich
• Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil

Abstract

Early detection of cancer is essential to increase the chance of cure, but unfortunately for many types of cancer there are no efficient methodologies at low cost. This project aims to develop biosensors for the early detection of colorectal and thyroid cancer by detecting the BRAF-V600E biomarker. Binary metal oxides synthesized with the coprecipitation method will be used to construct the architecture of the films to increase the specificity of the biosensor and the detection signal. The films will be constructed using physical and chemical self-assembling techniques, in multilayers with controlled order and thickness. The optimization of film fabrication conditions and characterization of nanostructures will be carried out with various experimental techniques, including electronic and vibrational spectroscopies, polarization-modulated infrared reflection absorption spectroscopy (PM-IRRAS) and microscopy techniques. The detection of the analyte will be performed through measurements of electrochemical impedance in standard solutions. The aim is to obtain low cost sensors with fast response and high sensitivity for the biomarker. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CAGNANI, GIOVANA ROSSO; IBANEZ-REDIN, GISELA; TIRICH, BEATRIZ; GONCALVES, DEBORA; BALOGH, DEBORA T.; OLIVEIRA JR, OSVALDO N.. Fully-printed electrochemical sensors made with flexible screen-printed electrodes modified by roll-to-roll slot-die coating. BIOSENSORS & BIOELECTRONICS, v. 165, OCT 1 2020. (19/10693-0, 13/14262-7)