Effects of neonatal anoxia on spatial memory and place cells activity in adult rodents

• Grant number: 19/17677-0
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: December 01, 2019
• End date: November 30, 2020
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: Alexandre Hiroaki Kihara
• Grantee: Juliane Midori Ikebara
• Supervisor: Avishek Adhikari
• Host Institution: Centro de Matemática, Computação e Cognição (CMCC). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Institution abroad: University of California, Los Angeles (UCLA), United States
• Associated to the scholarship: 16/17329-3 - Characterization of the interneurons population and in vivo cortical and hippocampal electrophysiological activity of adult rats submitted to neonatal anoxia, BP.DR

Abstract

Anoxia is one of the most prevalent causes of neonatal morbidity and mortality, especially in preterm neonates, constituting an important public health concern due to the permanent neurological sequelae observed in patients. Oxygen deprivation triggers a series of simultaneous cascades, culminating in cell death mainly located in more vulnerable metabolic brain regions, such as the hippocampus. The hippocampus is a structure related to spatial memory and learning and many studies have shown specific cell related to spatial representation, the place cells. Furthermore, the place cells activity has a relationship with neural oscillations such theta and gamma rhythms. These oscillations are modulated by interneurons that contribute to inhibition of excitatory activity of pyramidal cells. Once neonatal anoxia causes a spatial memory deficit and alteration in the number of specific interneurons, in this project we intend to evaluate the activity of the place cells and the interneurons using in vivo calcium imaging during a behavioural test in animals submitted to anoxia to elucidate the importance of interneurons in the stability and recruitment of place cells.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

REIS, FERNANDO MCV; LEE, JOHANNES Y.; MAESTA-PEREIRA, SANDRA; SCHUETTE, PETER J.; CHAKERIAN, MEGHMIK; LIU, JINHAN; LA-VU, MIMI Q.; TOBIAS, BROOKE C.; IKEBARA, JULIANE M.; KIHARA, ALEXANDRE HIROAKI; et al. Dorsal periaqueductal gray ensembles represent approach and avoidance states. eLIFE, v. 10, MAY 6 2021. (17/08668-1, 14/05432-9, 19/17677-0)

SCHUETTE, PETER J.; IKEBARA, JULIANE M.; MAESTA-PEREIRA, SANDRA; TOROSSIAN, ANITA; SETHI, EKAYANA; KIHARA, ALEXANDRE H.; KAO, JONATHAN C.; REIS, FERNANDO M. C., V; ADHIKARI, AVISHEK. GABAergic CA1 neurons are more stable following context changes than glutamatergic cells. SCIENTIFIC REPORTS, v. 12, n. 1, p. 18-pg., 2022-06-20. (16/17329-3, 17/08668-1, 19/17677-0, 19/17892-8, 15/23092-3)