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Comparative evaluation of the incidence of inferior alveolar nerve paresthesia using articaine and mepivacaine in lower third molar surgeries

Grant number: 19/20812-6
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2020
Effective date (End): February 28, 2021
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Ana Paula Farnezi Bassi
Grantee:Guilherme Alexandre Silva Prado
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


This randomized, double-blind, crossover, stopped clinical trial aims to evaluate the incidence of postoperative pain and paraesthesia with two types of local anesthetics, articaine, and mepivacaine. A comparative study to evaluate the incidence of paresthesia between two anesthetics has not yet been performed in separate groups employed alone. For this, 20 individuals of both genders, between 16 and 35 years old, without local or systemic pathologies, having bilateral retained lower third molars, in similar positions, selected and submitted to surgery to remove them. Surgical intervention will always be performed by the same operator, with the administration of an anesthetic on each side, which will be chosen at random, defined by Excel 2018. Paracetamol 500 mg tablets are prescribed as medication for escape analgesia. The pain will be assessed by the visual scale at 11 points within 24 hours postoperatively. Paresthesia, if present, will be available at 7 postoperative days. All data will be submitted to statistical analysis, considering the significance level of 5%.

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