Due to the great interest of androgen signaling in castration-resistant prostate cancer, there is an urgency to identify new molecules that may in the future serve both as biomarkers and for therapeutic purposes in prostate cancer. In this sense, the cofactors of the androgen receptor emerge as attractive molecules, since the androgen receptor manages to recruit key enzymatic cofactors for this pathway. Moreover, it is known that some microRNAs may be involved in regulating the expression of these cofactors. In this way, we will mimic a hypercholesterolemic in vitro environment in castration-resistant prostate cancer line and evaluate the expression profile of the AR coactivator genes, the p160 family (SRC-1, SRC-2, and SRC-3)in addition to inducing the expression of miR-137 and its control in PC-3 cells.
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