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Study of the effect of miR-137 on cell line of castration resistant prostate cancer in a hypercholesterolemic environment

Grant number: 19/19138-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2020
Effective date (End): December 31, 2020
Field of knowledge:Health Sciences - Medicine - Surgery
Principal researcher:Sabrina Thalita dos Reis Faria
Grantee:Vitória Ghazarian Nunes
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Due to the great interest of androgen signaling in castration-resistant prostate cancer, there is an urgency to identify new molecules that may in the future serve both as biomarkers and for therapeutic purposes in prostate cancer. In this sense, the cofactors of the androgen receptor emerge as attractive molecules, since the androgen receptor manages to recruit key enzymatic cofactors for this pathway. Moreover, it is known that some microRNAs may be involved in regulating the expression of these cofactors. In this way, we will mimic a hypercholesterolemic in vitro environment in castration-resistant prostate cancer line and evaluate the expression profile of the AR coactivator genes, the p160 family (SRC-1, SRC-2, and SRC-3)in addition to inducing the expression of miR-137 and its control in PC-3 cells.

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