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Characterization of the cardiovascular and respiratory alterations of mice previously submitted to sustained hypoxia

Grant number: 19/21916-0
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2020
Effective date (End): January 31, 2021
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Benedito Honorio Machado
Grantee:Juliana Reis Souza
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:18/15957-2 - Astrocytic modulation on brainstem neurons involved with generation and control of sympathetic and respiratory activities in rodents submitted to hypoxia, AP.TEM


Earlier studies from our laboratory showed that young rats subjected to sustained hypoxia (HM - 24 hours - FiO2 = 0.1) had significant elevations in blood pressure, which were related to changes in sympathetic-respiratory coupling. Considering that the results in the literature regarding cardiovascular and respiratory alterations in mice submitted to hypoxic models are very varied, due to the different protocols of hypoxic challenges used, in the present project we will initially make a complete characterization of cardiovascular and respiratory alterations in mice. Submitted to the HM protocol that we used in our laboratory for the last 10 years for rats. The results to be obtained with the mice will be a first determining step to establish the appropriate MH protocol to promote cardiovascular and respiratory alterations similar to those observed in rats. Autonomic and respiratory responses to baro-and chemoreflex activation in mice subjected to sustained hypoxia will also be evaluated. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RODRIGUES, KARLA L.; SOUZA, JULIANA R.; BAZILIO, DARLAN S.; DE OLIVEIRA, MAURO; MORAES, MELINA P. S.; MORAES, DAVI J. A.; MACHADO, BENEDITO H.. Changes in the autonomic and respiratory patterns in mice submitted to short-term sustained hypoxia. Experimental Physiology, v. 106, n. 3, . (18/15957-2, 19/21916-0)

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