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Influence of Coutarea hexandra extract on the in vitro neuromuscular blockade-induced by Lachesis muta muta snake venom

Grant number: 19/21147-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2020
Status:Discontinued
Field of knowledge:Biological Sciences - Pharmacology - Autonomic Pharmacology
Principal Investigator:Yoko Oshima Franco
Grantee:Grazielle Delaroli Pilon
Home Institution: Pró-Reitoria de Pós-Graduação, Pesquisa, Extensão e Inovação. Universidade de Sorocaba (UNISO). Sorocaba , SP, Brazil

Abstract

Medicinal plants are one of the oldest forms of treatment, cure and disease prevention. Add medicinal value to certain plants becomes a way to preserve it in the nature against its devastation, seen the benefits it can bring to humanity. Ophidian accidents caused mainly by anthropic action must receive immediate attention by gravity that encases, as in the case of Lachesis muta, through early antivenom administration. However, in some communities, this attention is difficult by several factors and the search of alternatives and strategies to minimize the damage must be continually sought. The objective of this project is to evaluate the neutralizing ability of Coutarea hexandra hydroalcoholic extract against the neuromuscular blockade-induced by Lachesis muta snake venom. The pharmacological assays (preincubation and post venom models) will be made using mouse phrenic nerve-diaphragm preparations (ex vivo) through conventional myographic technique.