Investigation of neuroplasticity in the human brain with near-infrared spectroscopy

• Grant number: 19/21962-1
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: March 01, 2020
• End date: February 28, 2022
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Rickson Coelho Mesquita
• Grantee: Sergio Luiz Novi Junior
• Host Institution: Instituto de Física Gleb Wataghin (IFGW). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology, AP.CEPID

Abstract

The brain is a complex and dynamical system that is always modifying itself to adapt and evolve. This capability of changing constantly is known as brain plasticity, or neuroplasticity. Although neuroplasticity is appointed as the key cerebral feature to brain reorganization and development, the study of neuroplasticity is restricted to the limitations of current neuroimaging modalities, such as electroencephalography (EEG) and functional Magnetic Resonance Imaging (fMRI). The goal of this project is to employ Near-Infrared Spectroscopy (NIRS) to assess neuroplasticity based on hemodynamic fluctuations of the brain during both the resting state and functional activation. NIRS is a neuroimaging technique with potential to overcome some of the limitations presented by fMRI and EEG due to its high specificity, high temporal resolution and portability. We first attempt to validate and compare NIRS-based functional networks with multimodal methods. Then, we aim to evaluate effects of neuroplasticity with NIRS in two different scenarios: during rehabilitation of stroke patients and during brain development of infants. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NOVI, SERGIO LUIZ; FORERO, EDWIN JOHAN; IVAN RUBIANES SILVA, JOSE ANGEL; DE SOUZA, NICOLAS GABRIEL S. R.; MARTINS, GIOVANI GRISOTTI; QUIROGA, ANDRES; WU, SHIN-TING; MESQUITA, RICKSON C.. Integration of Spatial Information Increases Reproducibility in Functional Near-Infrared Spectroscopy. FRONTIERS IN NEUROSCIENCE, v. 14, JUL 28 2020. (13/07559-3, 12/02500-8, 19/21962-1)

LIBARDI BERTACHINI, ANA LIVIA; JANUARIO, GABRIELA CINTRA; NOVI, SERGIO LUIZ; MESQUITA, RICKSON COELHO; ROMANO SILVA, MARCO AURELIO; QUEIROZ ANDRADE, GLAUCIA MANZAN; DE RESENDE, LUCIANA MACEDO; DE MIRANDA, DEBORA MARQUES. Hearing brain evaluated using near-infrared spectroscopy in congenital toxoplasmosis. SCIENTIFIC REPORTS, v. 11, n. 1, MAY 12 2021. (16/22990-0, 19/21962-1, 13/07559-3)

WU, SHIN-TING; SILVA, JOSE ANGEL IVAN RUBIANES; NOVI, SERGIO LUIZ; DE SOUZA, NICOLAS GABRIEL S. R.; FORERO, EDWIN JOHAN; MESQUITA, RICKSON C.. Accurate Image-guided (Re)Placement of NIRS Probes. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, v. 200, MAR 2021. (12/02500-8, 19/21962-1, 13/07559-3, 16/22990-0)

AYAZ, HASAN; BAKER, WESLEY B.; BLANEY, GILES; BOAS, DAVID A.; BORTFELD, HEATHER; BRADY, KENNETH; BRAKE, JOSHUA; BRIGADOI, SABRINA; BUCKLEY, ERIN M.; CARP, STEFAN A.; et al. Optical imaging and spectroscopy for the study of the human brain: status report. NEUROPHOTONICS, v. 9, p. 65-pg., 2022-08-01. (18/04654-9, 19/21962-1, 16/22990-0, 13/07559-3, 21/05332-8, 18/21934-5)

NOVI, SERGIO L.; CARVALHO, ALEX C.; FORTI, R. M.; CENDES, FERNADO; YASUDA, CLARISSA L.; MESQUITA, RICKSON C.. Revealing the spatiotemporal requirements for accurate subject identification with resting-state functional connectivity: a simultaneous fNIRS-fMRI study. NEUROPHOTONICS, v. 10, n. 1, p. 16-pg., 2023-01-01. (12/02500-8, 13/07559-3, 16/22990-0, 19/21962-1, 14/25486-6)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

NOVI JUNIOR, Sergio Luiz. Investigação da neuroplasticidade funcional no cérebro humano com espectroscopia no infravermelho próximo. 2022. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Instituto de Física Gleb Wataghin Campinas, SP.