Porous hydroxyapatite synthesis that mimics the physicochemical characteristics of Bio-Oss for use as a bone graft in dentistry

• Grant number: 19/20639-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2020
• End date: January 31, 2021
• Field of knowledge: Health Sciences - Dentistry - Dental Materials
• Principal Investigator: Luis Geraldo Vaz
• Grantee: Ana Paula Bosco Gomes
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

A bone graft is a material widely used in areas such as orthopedics, maxillary oral surgery, and dentistry. Some of the most widely used materials in the world are produced through the extraction of bovine and porcine bones, however, they present residual organic contaminants. In addition, the process can be highly aggressive with the use of strong alkalis and oxidants, being highly costly and requiring bone traceability. The aim of this study is to propose a clean synthesis process, that is ie, without using animal materials, and without forming toxic waste, besides being easily easy to produce with hydroxyapatite formation with a minimum purity of 99%, and mainly as use for efficient bone graft formation. To characterize this material, the following tests will be performed: a) determination of particle porosity, b) real density, c) pore distribution by BET method, d) pore size distribution by mercury intrusion porosimetry, e) determination of phases present by X-ray diffraction, f) X-ray fluorescence spectroscopy, g) cytotoxicity, cell viability and adhesion tests, and h) particle morphology by scanning electron microscopy. The results obtained will indicate its viability for use as a bone graft.