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Synthesis and structural and mechanical characterization of dense bovine hydroxyapatite bioceramic with added Y-TZP nanoparticle and whiskers

Grant number: 20/01715-7
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): September 01, 2020
Effective date (End): August 31, 2023
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Ana Flávia Sanches Borges
Grantee:Lucas José de Azevedo Silva
Host Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil


The synthesis of a dense bovine hydroxyapatite (HA) bioceramics can be a promising crystalline biomaterial, matching biochemical advantages of HA with the production of a sustainable material from bovine bone residues. With application for use in grafts already widespread in the medical and dental field, the HA has high biocompatibility already known today, but consists of a material with low mechanical strength. Applying the use of nanotechnology, it is expected to achieve significant improvements in the mechanical properties of this material. The aim of the present study is to evaluate the role of different percentages of zirconia nanoparticles (Y-TZP) (1, 5 and 8%) and zirconia whiskers (Y-TZP) (1, 5 and 8%) in the microstructure and characteristics by X-ray Diffractometry (XRD), Spectrometry Fourrier Transform Infrared (FTIR) and Scanning Electron Microscopy (SEM) and the following mechanical analyzes: biaxial flexural strength, reliability and fracture toughness by flexion fracture surface analysis. The tests will also be performed on pure HA-based and Y-TZP ceramics, representing experimental and commercial control groups, respectively. After normality test, ANOVA (± = 0.05), followed by Tukey post test will be used for comparison between groups. The flexural strength data will be adjusted in the Weibull distribution (Reliasoft +++) for the longevity data variability distribution model. The results of this study will result in an insight into the mechanical behavior of this new experimental material that may be used in future dental applications. (AU)

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