Study of the influence of nanocarriers and drug combinations on cell viability and migration

• Grant number: 20/04633-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2020
• End date: April 30, 2021
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Principal Investigator: Luciana Biagini Lopes
• Grantee: Isabella Draszesski Malagó
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 18/13877-1 - Nanocarriers for localized treatment and chemoprevention of breast tumors, AP.JP2

Abstract

Chemoprevention is an important strategy for reduction of breast cancer incidence. However, women's adherence to the currently available strategies is very low mostly because of the severe adverse effects. Our group has been focusing on the development and evaluation of nanocarriers containing drug combinations as potential new strategies for pharmacological prevention of breast cancer. In this project, we will assess whether and how (i) nanoencapsulation and (ii) combination of drugs influence the viability and migration of breast cancer (MCF7 and T47D) cells. Additionally, effects on non-tumoral (MCF10) cells will be assessed to verify safety and selectivity. We will focus on combinations of piplartine, fenretinide, 5-fluorouracyl and perillyl alcohol to determine additive and synergistic effects, and these drugs will be incorporated at selected combinations in lipid nanocarriers.