Toxic effects of microcystin-LR on white musculature of Astyanax altipanae fish

• Grant number: 19/24438-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: May 01, 2020
• End date: August 31, 2021
• Field of knowledge: Biological Sciences - Genetics - Mutagenesis
• Principal Investigator: Bruno Fiorelini Pereira
• Grantee: Nátali Bosquê Rodrigues
• Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil

Abstract

The diagnosis of tissue damage, as well as its direct relationship with its cause, has been a challenge for vertebrate studies. In fish, this line of thought is little explored, due to the extensive tissue differences of this group compared to mammals, which have some methodologies already well described and consolidated. One way to understand the evolution of lesions may be through the exposure of a specimen to toxic agents since the development of any pathologies is directly related to the concentration of contaminant and the exposure time. Thus, this project aims to identify lesions in the white musculature of Astyanax altiparanae fish caused by the microcystin -LR toxin (common in eutrophication events) through qualitative and quantitative morphological techniques. We thus intend to obtain results that are relevant to the advancement of fish and human toxicology, considering that fish consumption is very relevant in our society, as well as assisting in the review and / or creation of new environmental.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

RODRIGUES, NATALI BOSQUE; PITOL, DIMITRIUS LEONARDO; DE FIGUEIREDO, FELLIPE AUGUSTO TOCCHINI; LIMA, ANA CLAUDIA TENFEN DAS CHAGAS; HENRY, THEODORE BURDICK; ISSA, JOAO PAULO MARDEGAN; UMBUZEIRO, GISELA DE ARAGAO; PEREIRA, BRUNO FIORELINI. Microcystin-LR at sublethal concentrations induce rapid morphology of liver and muscle tissues in the fish species Astyanax altiparanae (Lambari). Toxicon, v. 211, p. 9-pg., 2022-05-01. (16/02946-7, 19/24438-1)