Lung diseases and COVID diagnosis from computed tomography images using explainable deep learning

• Grant number: 19/21964-4
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): July 01, 2020
• Effective date (End): March 31, 2024
• Field of knowledge: Engineering - Electrical Engineering
• Principal Investigator: Roberto de Alencar Lotufo
• Grantee: Diedre Santos do Carmo
• Host Institution: Faculdade de Engenharia Elétrica e de Computação (FEEC). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology, AP.CEPID
• Associated scholarship(s): 22/02344-8 - Automated longitudinal segmentation of lung and COVID-19 findings exploring self-supervised learning and polymorphic training, BE.EP.DR

Abstract

The use of deep learning for medical decision support over Computed Tomography (CT) and X-Ray images in the current COVID pandemic is a hot topic in medical imaging processing. Research has shown that CT images display signs of COVID infection, which are more prevalent in severe cases. Some methods have already been proposed, mainly using transfer learning techniques over already proven methods, for classification and segmentation of COVID related CT images. Manual annotations are considered to be a gold-standard when developing and evaluating current automated methods, and those are still lacking specially for segmentation. This lack of gold standard data paired with the possibility of overfitting to specific characteristics of the scarce public data currently available puts in check the reliability of those methods. Special attention has to be drawn to lung diseases that present similar findings in CT, and could lead to confusion when evaluated by a method specialized in COVID and NON-COVID cases. In this project, we propose to develop an automated pathology diagnosis method, able to be explainable through two different tasks, classification and accurate segmentation of lung and lung findings in chest CT images, while taking into account the possible presence of other diseases. We intend to build a large cohort of public and private data for evaluation of our method, including more than 3000 classification volumes presenting diverse lung diseases and 124 (possibly growing) labeled segmentation CT volumes, in a partnership with the Radvid19 São Paulo Government initiative and São Paulo hospitals, where we already have promising preliminary results. We also will have access to data from our partnership with the BRAINN (2013/07559-3) and COVID (2020/07200-9) FAPESP CEPID projects, where CT volumes from COVID patients are being acquired from Campinas' Hospital das Clínicas. This data is going through all the necessary ethical approval steps. We plan to use novel segmentation and classification architectures based on recent advances in semantic segmentation, and experimentation with a paradigm shift in medical imaging processing, namely the use of transformers. We will compare our methodology with state-of-the-art techniques in public datasets and subject it to qualitative evaluation from physicians. Plans for a BEPE are part of this PhD project. (AU)

Scientific publications

(8)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

CARMO, DIEDRE; CAMPIOTTI, ISRAEL; RODRIGUES, LIVIA; FANTINI, IRENE; PINHEIRO, GUSTAVO; MORAES, DANIEL; NOGUEIRA, RODRIGO; RITTNER, LETICIA; LOTUFO, ROBERTO. Rapidly deploying a COVID-19 decision support system in one of the largest Brazilian hospitals. HEALTH INFORMATICS JOURNAL, v. 27, n. 3, JUL 2021. (13/07559-3, 19/21964-4)

CARMO, DIEDRE; CAMPIOTTI, ISRAEL; FANTINI, IRENE; RODRIGUES, LIVIA; RITTNER, LETICIA; LOTUFO, ROBERTO; ROMERO, E; COSTA, ET; BRIEVA, J; RITTNER, L; et al. Multitasking segmentation of lung and COVID-19 findings in CT scans using modified EfficientDet, UNet and MobileNetV3 models. 17TH INTERNATIONAL SYMPOSIUM ON MEDICAL INFORMATION PROCESSING AND ANALYSIS, v. 12088, p. 10-pg., 2021-01-01. (19/21964-4)

PINHEIRO, GUSTAVO RETUCI; BRUSINI, LORENZA; CARMO, DIEDRE; PROA, RENATA; ABREU, THAYS; APPENZELLER, SIMONE; MENEGAZ, GLORIA; RITTNER, LETICIA. Thalamus Segmentation Using Deep Learning with Diffusion MRI Data: An Open Benchmark. APPLIED SCIENCES-BASEL, v. 13, n. 9, p. 21-pg., 2023-04-23. (19/21964-4, 13/07559-3)

BEAUFERRIS, YOUSSEF; TEUWEN, JONAS; KARKALOUSOS, DIMITRIOS; MORIAKOV, NIKITA; CAAN, MATTHAN; YIASEMIS, GEORGE; RODRIGUES, LIVIA; LOPES, ALEXANDRE; PEDRINI, HELIO; RITTNER, LETICIA; et al. Multi-Coil MRI Reconstruction Challenge-Assessing Brain MRI Reconstruction Models and Their Generalizability to Varying Coil Configurations. FRONTIERS IN NEUROSCIENCE, v. 16, p. 15-pg., 2022-07-06. (19/21964-4)

CARMO, DIEDRE; RITTNER, LETICIA; LOTUFO, ROBERTO; CRIMI, A; BAKAS, S. MultiATTUNet: Brain Tumor Segmentation and Survival Multitasking. BRAINLESION: GLIOMA, MULTIPLE SCLEROSIS, STROKE AND TRAUMATIC BRAIN INJURIES (BRAINLES 2020), PT I, v. 12658, p. 11-pg., 2021-01-01. (13/07559-3, 19/21964-4)

RODRIGUES, JOANY; PINHEIRO, GUSTAVO; CARMO, DIEDRE; RITTNER, LETICIA; ROMERO, E; COSTA, ET; BRIEVA, J; RITTNER, L; LINGURARU, MG; LEPORE, N. Volumetric Segmentation of the Corpus Callosum: Training a Deep Learning model on diffusion MRI. 17TH INTERNATIONAL SYMPOSIUM ON MEDICAL INFORMATION PROCESSING AND ANALYSIS, v. 12088, p. 10-pg., 2021-01-01. (13/07559-3, 19/21964-4)

RODRIGUES, JOANY; CARMO, DIEDRE; ABREU, THAYS; APPENZELLER, SIMONE; RITTNER, LETICIA; BRIEVA, J; GUEVARA, P; LEPORE, N; LINGURARU, MG; RITTNER, L; et al. Can incomplete silver standard labels improve performance of DTI-based volumetric segmentation of the corpus callosum ?. 18TH INTERNATIONAL SYMPOSIUM ON MEDICAL INFORMATION PROCESSING AND ANALYSIS, v. 12567, p. 10-pg., 2023-01-01. (19/21964-4, 13/07559-3)

CARMO, D. S.; TUDAS, R. A.; COMELLAS, A. P.; PEZZULO, A. A.; VILLACRESES, R. A.; CHO, J. L.; ZABNER, J.; RITTNER, L.; LOTUFO, R. A.; REINHARDT, J. M.; et al. Evidence of Post-infection Vaccination Correlation With the Severity of Opacities and Consolidations on the Lung Parenchyma of Post-acute SARS-CoV-2 Patients. American Journal of Respiratory and Critical Care Medicine, v. 207, p. 1-pg., 2023-05-01. (19/21964-4, 22/02344-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

CARMO, Diedre Santos do. Segmentação de estruturas pulmonares e lesões na tomografia computadorizada com dados heterogêneos. 2024. Doctoral Thesis - Universidade Estadual de Campinas (UNICAMP). Faculdade de Engenharia Elétrica e de Computação Campinas, SP.