Linezolid was the first antibiotic in the Oxazolidinone class to be synthesized for pharmaceutical purposes. Being an inhibitor of bacterial protein synthesis, the molecule has become very favorable in combating diseases caused by gram-positive multidrug-resistant bacteria. The biological properties and theoretical and experimental studies have clarified, in recent years, its therapeutic action. In the present research project we will study from the point of view of computer simulation the interactions and possible conformations adopted by linezolid in its isolated form and when complexed at the interaction site of the 50S ribosomal subunit. From the conformations obtained in the isolated state and in the presence of solvents (implicit and explicit) we will compare it with that obtained by the x-ray diffraction technique. The spectroscopic properties of linezolid such as the absorption of circularly polarized light and in the ultraviolet region will also be studied. The research project has as main objective to provide subsidies for the understanding of the main interactions and conformations adopted by linezolid when forming the complex with the 50S unit and its purine and pyrimidine bases present in the interaction site.
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