In vivo efficacy of Cryptocarya (Lauraceae) extracts on Candida albicans biofilm

• Grant number: 20/03755-6
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2020
• End date: August 31, 2021
• Field of knowledge: Health Sciences - Dentistry - Dental Clinics
• Principal Investigator: Janaina Habib Jorge
• Grantee: Caroline Correa de Oliveira
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

To evaluate the effectiveness of extracts of the species of Cryptocarya in inactivating the biofilm of Candida albicans present in the lingual dorsum of mice with induced candidiasis. In a first study, the plants will be evaluated in relation to the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (CFM) of the planktonic cells of Candida albicans. The effectiveness of these extracts in inactivating the biofilm of Candida albicans present in the lingual dorsum of mice with induced candidosis will be determined. For this, after treatments with the medicinal plant, the fungi present on the lingual dorsum of mice will be collected and counting of colony forming units. Histological analysis of the samples will also be performed after the different treatments. For each study, the data will be subjected to the most appropriate statistical analysis, with a 5% significance level.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ZOCCOLOTTI, JACQUELINE DE OLIVEIRA; CAVALHEIRO, ALBERTO JOSE; TASSO, CAMILLA OLGA; DE OLIVEIRA, CAROLINE CORREA; RIBAS, BEATRIZ RIBEIRO; FERRISSE, TULIO MORANDIN; DE SOUZA COSTA, CARLOS ALBERTO; JORGE, JANAINA HABIB. In vivo antifungal activity and biocompatibility of Cryptocarya moschata. Archives of Microbiology, v. 204, n. 9, p. 9-pg., 2022-09-01. (20/03755-6)