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Characterization of antitumor activity between the interaction between mesenchymal stem cells and canine oral melanoma cells

Grant number: 20/02255-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2020
Effective date (End): July 31, 2021
Field of knowledge:Agronomical Sciences - Veterinary Medicine - Animal Pathology
Principal Investigator:Carlos Eduardo Fonseca Alves
Grantee:Teng Fwu Shing
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

A lot of studies have been demonstrating the importance of tumor microenvironment for their development and progression, which makes it essential to search for new ways to prevent its development. The use of mesenchymal stem cells (MSCs) as a new therapeutic for several tumors shown dubious results concerning its therapeutic capacity. In vivo and in vitro studies suggest that there is a specific antitumor effect from this interaction, however, other studies show tumor growth when using this therapeutic model, therefore, that confirms that more studies are necessary to understand your dynamics with tumor cells and their microenvironment. Canine melanoma is a target of immunomodulatory approaches in order to intensify the immune system's anti-tumor response and induce cancer regression. MSCs have several immunomodulatory properties due to your production of cytokines, which can promote suppression or stimulation of the immune system, making their relationship extremely complex and dependent on the microenvironment that is involved. This study aims to understand the relationship between MSCs and canine melanoma promoting an explanation of the dynamics between them and your effects on T lymphocyte antitumor activity through a co-culture with canine melanoma cells (MeLn and TLM-1), mesenchymal stem cells from dogs, and T lymphocytes isolated from peripheral blood samples.