Modification of amino acids and their derivatives for the preparation of polymers by Diels Alder reactions

• Grant number: 20/09059-1
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: August 01, 2020
• End date: July 31, 2024
• Field of knowledge: Engineering - Biomedical Engineering
• Principal Investigator: Eliane Trovatti
• Grantee: Bruna Carolina Dorm
• Host Institution: Universidade de Araraquara (UNIARA). Associação São Bento de Ensino. Araraquara , SP, Brazil
• Associated research grant: 17/18782-6 - Click chemistry platform for the development of polymer-based materials for regenerative medicine, AP.JP
• Associated scholarship(s): 22/09328-8 - Chemical modification of starch and cysteine and subsequent reaction by the addition of Thiol-Michael to obtain polysaccharide conjugates for biomedical applications, BE.EP.DD

Abstract

The demand for materials with properties suitable for use in Medicine Regenerative growth is increasing, especially with regard to polymers to be used as biological supports (scaffolds). This proposal has as main objective the synthesis of new furanic monomers based on amino acids and/or their dipeptide derivatives and the synthesis of polymers from these monomers. The proposal is the use of amino acids as building blocks of the polymeric structure due to the biocompatibility of themselves. The chemical bonding strategy between monomers through the Diels reaction Alder aims to use an efficient reaction, with few by-products, high efficiency, in addition to introduce amine and hydroxyl groups in the polymer structure, which can lead to materials with differentiated properties, not yet studied or developed for possible application in the biomedical field. (AU)