Electroanalytical determination of calcium channel blockers making use of molecularly imprinted polymers

• Grant number: 20/04268-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: October 01, 2020
• End date: June 30, 2021
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Luís Francisco Moreira Gonçalves
• Grantee: Heitor Gabriel Martins Sposito
• Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 18/14425-7 - A new synergetic path for gas-diffusion microextraction (GDME) making use of molecular imprinted polymers (MIPs), AP.JP

Abstract

In this project it is intended to develop molecular printing polymers (MIPs) by electropolymerization for the development of portable analytical sensors, aiming the analysis of chemical compounds, specifically, calcium channel blockers, such as diltiazem. Diltiazem is a drug that belongs to the group of benzothiazepines, a type of calcium channel blocker that acts as a vasodilator, reduces heart rate and slows down atrioventricular conduction. Diltiazem is an antianginal (reduces severe chest pain), antihypertensive (dilates blood vessels, reducing blood pressure) and antiarrhythmic (stabilizes the heart rhythm). As it is eliminated by urine, there is a wide range of samples, in addition to making it possible to control its dosage in humans, since in high concentrations diltiazem can cause a decrease in the heart-rate, atrioventricular block (closing of the atria and ventricles that allow blood to circulate in the heart), heart failure (malfunction of the heart), hypotension (very low pressure). The use of MIPs is recognized as one of the fastest (in particular by electropolymerization) and powerful methods for the creation of synthetic receptors, since it is a technique used to design artificial receptors with a high selectivity and specificity for a given analyses, on account of having the property of copying natural biological receptors such as antibodies and enzymes.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SPOSITO, HEITOR GABRIEL MARTINS; LOBATO, ALNILAN; TASIC, NIKOLA O.; MALDANER, ADRIANO O.; PAIXAO, THIAGO R. L. C.; GONCALVES, LUIS MOREIRA. Swift electrochemical sensing of diltiazem employing highly-selective molecularly-imprinted 3-amino-4-hydroxybenzoic acid. JOURNAL OF ELECTROANALYTICAL CHEMISTRY, v. 911, p. 7-pg., 2022-03-11. (18/13922-7, 18/14425-7, 19/16491-0, 19/11214-8, 17/10522-5, 18/08782-1, 20/04268-1)