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Development of a cellular assay to measure SARS-CoV-2 Nsp3 macrodomain activity in vitro

Grant number: 20/11162-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2020
Effective date (End): June 30, 2022
Field of knowledge:Biological Sciences - Biochemistry - Molecular Biology
Principal Investigator:Nicolas Carlos Hoch
Grantee:Lilian Cristina Russo Vieira
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:20/05317-6 - Inhibition of the viral macrodomain as a strategy for Coronavirus treatment, AP.R

Abstract

The SARS-CoV-2 Nsp3 macrodomain is a promising target for COVID-19 treatment. As part of an international effort to identify viral macrodomain inhibitors, this post-doctoral fellowship is aimed specifically at developing a cellular assay to detect the catalytic activity of the ectopically expressed viral macrodomain in human cells and use this assay to refine the list of candidate compounds for further tests. (AU)