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Exploring the potential of plasma activated liquid (PAL): characterization of plasma and application of PAL in endodontic treatment

Grant number: 20/10450-7
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Start date: November 01, 2020
End date: August 25, 2022
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Rodrigo Savio Pessoa
Grantee:William Chiappim Junior
Host Institution: Divisão de Ciências Fundamentais (IEF). Instituto Tecnológico de Aeronáutica (ITA). Ministério da Defesa (Brasil). São José dos Campos , SP, Brazil
Associated research grant:19/05856-7 - Use of low temperature atmospheric pressure plasma in dentistry: from laboratory bench to clinics, AP.TEM

Abstract

The project will explore the generation of Plasma Activated Liquid (PAL) for applications related to dentistry. Due to the considerable promise of technology, there is an urgent need to develop a pilot scale PAL system that can be used to generate results with real relevance, especially in the dental field. This postdoctoral project will focus on: (i) developing and characterizing a PAL generation system and (ii) applying plasma-activated liquids in endodontic treatment. For this, techniques of mass spectrometry and optical emission spectroscopy will be used to study the physical and chemical properties of the generated plasmas, as well as their interaction with PAL. For microbiological tests, argon / air plasmas in physiological solution will be applied and subsequently these liquids will be evaluated for antimicrobial activity in dual-species biofilms of Candida albicans (SC 5314) and Enterococcus faecalis (ATCC 29212). Once the best conditions for inactivating the biofilms are verified, experiments will be carried out where the dual-species biofilms will be grown in the root canal of 50 fragments of uniradicular bovine teeth and treated with plasma activated liquid (PAL). Through microbiological analysis and the liquid treated with plasma, the PAL's actions on microorganisms will be discussed, as well as a protocol for the use of PAL in the dental environment will be established. Finally, a PAL generation system will be designed for use in the dental office.

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications (9)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MILHAN, NOALA VICENSOTO MOREIRA; CHIAPPIM, WILLIAM; SAMPAIO, ALINE DA GRACA; VEGIAN, MARIANA RAQUEL DA CRUZ; PESSOA, RODRIGO SAVIO; KOGA-ITO, CRISTIANE YUMI. Applications of Plasma-Activated Water in Dentistry: A Review. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 8, p. 26-pg., . (20/10450-7, 19/25652-7, 21/00046-7, 19/05856-7)
SAMPAIO, ALINE DA GRACA; CHIAPPIM, WILLIAM; MOREIRA MILHAN, NOALA VICENSOTO; NETO, BENEDITO BOTAN; PESSOA, RODRIGO; KOGA-ITO, CRISTIANE YUMI. Effect of the pH on the Antibacterial Potential and Cytotoxicity of Different Plasma-Activated Liquids. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 23, n. 22, p. 21-pg., . (19/05856-7, 19/25652-7, 21/00046-7, 20/10450-7)
CHIAPPIM, WILLIAM; NETO, BENEDITO BOTAN; SHIOTANI, MICHAELA; KARNOPP, JULIA; GONCALVES, LUAN; CHAVES, JOAO PEDRO; SOBRINHO, ARGEMIRO DA SILVA; LEITAO, JOAQUIM PRATAS; FRAGA, MARIANA; PESSOA, RODRIGO. Plasma-Assisted Nanofabrication: The Potential and Challenges in Atomic Layer Deposition and Etching. NANOMATERIALS, v. 12, n. 19, p. 32-pg., . (21/03620-6, 20/10450-7, 18/01265-1)
CHIAPPIM, WILLIAM; FRAGA, MARIANA AMORIM; FURLAN, HUMBER; ARDILES, DAVID CESAR; PESSOA, RODRIGO SAVIO. The status and perspectives of nanostructured materials and fabrication processes for wearable piezoresistive sensors. MICROSYSTEM TECHNOLOGIES-MICRO-AND NANOSYSTEMS-INFORMATION STORAGE AND PROC, v. 28, n. 7, p. 20-pg., . (18/01265-1, 20/10450-7)
CHIAPPIM, WILLIAM; SAMPAIO, ALINE DA GRACA; MIRANDA, FELIPE; FRAGA, MARIANA; PETRACONI, GILBERTO; DA SILVA SOBRINHO, ARGEMIRO; KOSTOV, KONSTANTIN; KOGA-ITO, CRISTIANE; PESSOA, RODRIGO. Antimicrobial Effect of Plasma-Activated Tap Water on Staphylococcus aureus, Escherichia coli, and Candida albicans. WATER, v. 13, n. 11, p. 16-pg., . (19/05856-7, 20/10450-7, 19/25652-7, 18/01265-1)
CHIAPPIM, WILLIAM; SAMPAIO, ALINE DA GRACA; MIRANDA, FELIPE; FRAGA, MARIANA; PETRACONI, GILBERTO; DA SILVA SOBRINHO, ARGEMIRO; KOSTOV, KONSTANTIN; KOGA-ITO, CRISTIANE; PESSOA, RODRIGO. ntimicrobial Effect of Plasma-Activated Tap Water on Staphylococcus aureus, Escherichia coli, and Candida albican. WATER, v. 13, n. 11, . (19/25652-7, 19/05856-7, 18/01265-1, 20/10450-7)
CHIAPPIM, WILLIAM; SAMPAIO, ALINE; MIRANDA, FELIPE; PETRACONI, GILBERTO; DA SILVA SOBRINHO, ARGEMIRO; CARDOSO, PAULO; KOSTOV, KONSTANTIN; KOGA-ITO, CRISTIANE; PESSOA, RODRIGO. Nebulized plasma-activated water has an effective antimicrobial effect on medically relevant microbial species and maintains its physicochemical properties in tube lengths from 0.1 up to 1.0 m. Plasma Processes and Polymers, v. 18, n. 11, . (19/25652-7, 19/05856-7, 20/10450-7)
KODAIRA, FELIPE VICENTE DE PAULA; LEAL, BRUNO HENRIQUE SILVA; TAVARES, THAYNA FERNANDES; QUADE, ANTJE; HEIN, LUIS ROGERIO DE OLIVEIRA; CHIAPPIM, WILLIAM; KOSTOV, KONSTANTIN GEORGIEV. Simultaneous Treatment of Both Sides of the Polymer with a Conical-Shaped Atmospheric Pressure Plasma Jet. POLYMERS, v. 15, n. 2, p. 14-pg., . (19/05856-7, 20/10450-7)
CHIAPPIM, WILLIAM; TESTONI, GIORGIO; MIRANDA, FELIPE; FRAGA, MARIANA; FURLAN, HUMBER; SARAVIA, DAVID ARDILES; SOBRINHO, ARGEMIRO DA SILVA; PETRACONI, GILBERTO; MACIEL, HOMERO; PESSOA, RODRIGO. Effect of Plasma-Enhanced Atomic Layer Deposition on Oxygen Overabundance and Its Influence on the Morphological, Optical, Structural, and Mechanical Properties of Al-Doped TiO2 Coating. MICROMACHINES, v. 12, n. 6, . (20/10450-7, 18/01265-1)