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Metabolomic analysis by Nuclear Magnetic Resonance (NMR) and mass spectrometry (LC-MS) of blood samples from individuals submitted to cardiorespiratory rehabilitation.

Grant number: 20/13939-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): December 01, 2020
Effective date (End): November 30, 2022
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal researcher:Antonio Gilberto Ferreira
Grantee:Alex Castro
Home Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil
Associated research grant:16/22215-7 - Impact of inspiratory muscle training and aging on metabolic maping and autonomic modulation at rest and on cardiovascular, respiratory and metabolic responses to exercise in healthy men, AP.TEM

Abstract

NMR and MS techniques have proven to be very useful analytical tools, especially in the last decade, in the metabolomic/metabonomic study of animal and plant organisms. The combination of these orthogonal techniques allows the analysis of matrices looking for target or non-target compounds and obtaining information on the molecular structure of the compounds involved in their discrimination. In addition, quantitative results can be obtained with a minimum sample preparation time. On the other hand, the positive results generated by the use of inspiratory muscle training (IMT) in active and non-active healthy individuals have made this type of intervention one of the most studied in the last decades. IMT has already been used as an integral part of cardiorespiratory rehabilitation in individuals with respiratory muscle weakness and currently appears as an alternative to improve the athletic performance of amateur and elite athletes by reducing the sensation of dyspnea in these individuals. In addition, regular physical activity is one of the main tools for healthy aging, so the metabolic characterization of active and sedentary aging can elucidate metabolic changes during the aging process.

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