Evaluation of Bone Metabolism Parameters by HR-pQCT and Histomorphometry in Rheumatoid Arthritis and Juvenile Idiopathic Arthritis Patients: Association with Clinical and Genetic Variables

• Grant number: 20/14223-5
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: January 01, 2021
• End date: April 30, 2024
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Eduardo Ferreira Borba Neto
• Grantee: Bidossessi Wilfried Hounkpe
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 16/00006-7 - Evaluation of bone metabolism parameters by HR-pQCT and histomorphometry in rheumatoid arthritis and juvenile idiopathic arthritis patients: association with clinical and genetic variables, AP.TEM
• Associated scholarship(s): 21/13590-7 - Defining shared immuno-inflammatory cell states and cell signalling circuits across autoimmune diseases, BE.EP.PD

Abstract

Rheumatoid arthritis (RA) is a systemic disease of autoimmune nature, which leads to osteoarticular impairment. Juvenile idiopathic arthritis (JIA) is a group of articular disease that affects individuals under 16 years of age. The polyarticular JIA has some peculiarities of RA: symmetrical involvement of small and large joints, bone destruction and disability, if not treated properly. Individuals with RA or JIA are subject to localized bone loss (juxta-articular) and systemic bone loss. In both forms of arthritis, localized bone involvement (erosions) and generalized (osteoporosis) lead to disability and worsening of life quality and increased morbidity and mortality. Risk factors for low bone mass in RA and JIA are multifactorial and include classical risk factors (gender, age, postmenopausal, low calcium intake and low vitamin D and smoking) as well as the intrinsic risk factors (inflammation and disease activity, immobility, and glucocorticoids use). These factors, together with a joint biomechanics changed, increase the risk of fractures. There are no studies in the literature that simultaneously evaluate the localized and generalized bone involvement in RA and JIA patients and genotype-phenotype association in relation to bone and articular involvement. The evaluation of bone involvement by more sensitive and specific cutting-edge methodologies, such as high resolution peripheral quantitative computed tomography (HR-pQCT), bone histomorphometry and trabecular bone score (TBS) will bring greater prospects for understanding the mechanisms associated with bone involvement in these diseases and help to treat these complications.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

NETO, LEVI H. JALES; HOUNKPE, BIDOSSESSI W.; FERNANDES, GEORGEA H.; TAKAYAMA, LILIAM; LOPES, NEUZA H. M.; PEREIRA, ALEXANDRE C.; PEREIRA, ROSA M. R.. Transcriptomic analysis of elderly women with low muscle mass: association with immune system pathway. AGING-US, v. 13, n. 17, p. 20992-21008, SEP 15 2021. (16/00006-7, 20/14223-5)