Effects of ischemic preconditioning on muscular damage induced by excentric exercise: randomized clinical trial placebo controlled

• Grant number: 20/04222-1
• Support Opportunities: Scholarships in Brazil - Master
• Start date: January 01, 2021
• End date: December 31, 2022
• Field of knowledge: Biological Sciences - Physiology - Physiology of Effort
• Principal Investigator: Franciele Marques Vanderlei
• Grantee: Eduardo Pizzo Junior
• Host Institution: Faculdade de Ciências e Tecnologia (FCT). Universidade Estadual Paulista (UNESP). Campus de Presidente Prudente. Presidente Prudente , SP, Brazil

Abstract

Eccentric exercise (EE) has been widely used in rehabilitation and improves physical activity due to its mechanical advantage and less in metabolic use, however, EE can cause altered muscle damage and altered muscle function, so it is necessary seek alternatives to reduce this damage caused by stress. Thus, ischemic preconditioning (PCI) can be seen as an aid to damage caused by EE, as it can decrease the deleterious effects of ischemia reperfusion, and can be used to perform the post-exercise recovery process. Objectives: the general objective of the present study will be to analyze and compare the effect of different pressures of PCI occlusion without muscle damage induced by eccentric exercise. The objectives should be: i) to analyze and compare, after eccentric exercise, as acute and delayed bets of the application of different pressures of PCI occlusion on clinical and cellular outcomes (sleep perception, alteration of sensitivity, muscle stiffness, muscle intensity and integrity) cell) and; ii) check if the PCI strategy applied to different occlusion pressures in eccentric exercise promotes deleterious effects on muscle function (assessed by maximum isometric voluntary contraction). Methods: a randomized placebo controlled clinical trial will be conducted with 80 men aged 18 to 35 years who will be randomly divided into four groups: PCI using total occlusion pressure (POT), PCI with 40% more than POT, placebo (10 mmHg ) and control. The PCI protocol will consist of four cycles of ischemia and reperfusion of five minutes each. All groups perform an EE protocol, starting, after the EE ends, 24, 48, 72 and 96 hours after exercise, being sequentially sequenced in creatine kinase (CK), blood lactate, pain on the visual scale (EVA), pain limit by pressure algometer, muscle thickness by ultrasound, bonuses, muscle stiffness and elasticity by myotonometry, cell integrity vectors by means of electrical bioimpedance (BIA) and maximum voluntary isometric contraction (CVIM) by isokinetic dynamometer. The descriptive statistical method and analysis of variation will be used for repeated measurement models. The level of significance will be p <0.05. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PIZZO JUNIOR, EDUARDO; DE SOUZA CAVINA, ALLYSIE PRISCILLA; LEMOS, LEONARDO KESROUANI; BIRAL, TAISE MENDES; PASTRE, CARLOS MARCELO; VANDERLEI, FRANCIELE MARQUES. Effects of different ischemic preconditioning occlusion pressures on muscle damage induced by eccentric exercise: a study protocol for a randomized controlled placebo clinical trial. Trials, v. 22, n. 1, MAY 5 2021. (20/04222-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

PIZZO JUNIOR, Eduardo. Effects of ischemic preconditioning on muscle damage induced by eccentric exercise: a randomized placebo-controlled clinical trial. 2023. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências e Tecnologia. Presidente Prudente Presidente Prudente.