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| Author(s): |
Eduardo Pizzo Junior
Total Authors: 1
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| Document type: | Master's Dissertation |
| Press: | Presidente Prudente. 2023-06-02. |
| Institution: | Universidade Estadual Paulista (Unesp). Faculdade de Ciências e Tecnologia. Presidente Prudente |
| Defense date: | 2023-04-04 |
| Advisor: | Franciele Marques Vanderlei |
| Abstract | |
Introduction: eccentric exercise (EE) has been widely used in rehabilitation and improvement of physical fitness due to its mechanical advantage and lower metabolic requirement, however, EE can induce muscle damage, providing structural changes and reduced muscle function, therefore, it is necessary to look for alternatives to reduce this damage caused by stress. Thus, ischemic preconditioning (IPC) can be seen as a helper in reducing the damage caused by EE, as it can reduce the deleterious effects of ischemia-reperfusion, and can be used to accelerate the post-exercise recovery process. Objective: to analyze and compare the acute responses and within 96 hours of the application of different ischemic preconditioning (IPC) occlusion pressures on clinical (perception of pain and recovery), cellular (CK and lactate) and physical (voluntary contraction maximum isometric [CVIM]). Methods: placebo-controlled randomized clinical trial with 80 healthy men aged 18 to 35 years, randomly divided into four groups: control, placebo (10 mmHg), PCI using total occlusion pressure (POT), PCI with 40% more than POT. The intervention protocol consisted of four cycles of ischemia and reperfusion of five minutes each. All groups performed initial evaluations, eccentric muscle damage protocol, evaluations immediately after the end of the eccentric damage, 24, 48, 72 and 96 hours after the damage, sequentially evaluating creatine kinase (CK), blood lactate, pain according to the scale visual analogue (VAS), recovery perception (LIKERT) and maximal isometric voluntary contraction (CVIM) by isokinetic dynamometer. Descriptive statistical method and generalized linear mixed model with significance of p<0.05 were used. Results: there was no difference between groups and interaction between groups vs. moments. When analyzing localized VAS and LIKERT, only the placebo group recovered in 72 hours. For overall EVA all groups except PCI-40% recovered within 24h. Regarding the CVIM, only the PCI-40% recovered in 48 hours, as for lactate, the PCI-40% and placebo groups recovered before the other groups, being in 13 minutes. For CK, the PCI-POT group showed a difference in 24h, while the other groups showed it after 72h, with the exception of PCI-40%, which was in 48h. Conclusion: PCI with different occlusion pressures does not have a protective effect when compared to the control and placebo groups. (AU) | |
| FAPESP's process: | 20/04222-1 - Effects of ischemic preconditioning on muscular damage induced by excentric exercise: randomized clinical trial placebo controlled |
| Grantee: | Eduardo Pizzo Junior |
| Support Opportunities: | Scholarships in Brazil - Master |