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Eficacy of an aerobic exercise protocol associated with photobiomodulatio with progressive dosing in the pain level and health-related quality of life of women with fibromyalgia

Grant number: 20/01513-5
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): December 01, 2020
Effective date (End): November 30, 2022
Field of knowledge:Health Sciences - Medicine
Principal researcher:Ana Claudia Muniz Renno
Grantee:Patrícia Gabrielli Vassão Alves Arakaki
Home Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil


Fibromyalgia (FM) is characterized by chronic generalized muscle pain, which affects mainly women. Several studies have already shown that aerobic exercises are effective for improving pain and quality of life in this population; other studies have already shown that photobiomodulation (PBM) is also effective in this regard. However, there is no consensus in the literature regarding the best parameters of FBM to treat patients with FM, as well as in progressive dosage throughout the treatment. Thus, the objective of this study will be to verify the effect of the association of an aerobic exercise protocol associated with FBM, with progressive dosage, in the level of pain and in the health-related quality of life of women with FM. Forty women will be randomized and divided into four groups: EAPG: exercise and active PBM group, EPPG: exercise and placebo PBM group, APG: active FBM group or PPG: placebo FBM group. Before the first session, after the last treatment session, and a follow-up of 26 and 52 weeks after the first assessment, pain will be assessed using the Visual Analogue Scale (VAS), pressure pain threshold, Impact of Fibromyalgia on quality of life, quality of life by SF-36, fatigue level by FSS, level of physical activity by IPAQ, Timed Up-and-Go Test (TUG) and functional capacity by the 6-minute Walk Test (6MWT). The interventions will last for 12 weeks, twice a week with the performance of aerobic exercise on a stationary bicycle and progression of load through the cardiorespiratory test.

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