Duration of the Effect of the Light Emitting Diode (LED) in the potentiation of therapy with mesenchymal stem cells of adipose tissue

• Grant number: 20/12547-8
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2021
• End date: January 31, 2022
• Field of knowledge: Biological Sciences - Biochemistry - Molecular Biology
• Principal Investigator: Andrey Jorge Serra
• Grantee: Vítor Pocani da Rocha
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil

Abstract

Mesenchymal stem cells (MSC) are studied as a mean of alternative therapy for several pathologies, because through paracrine effects of cytokines and secreted growth factors, they acquire mechanisms of therapeutic action. However, as the loss of MSCs is considerable in the transplanted area, it is necessary to use tools and different means to face this problem. Among these tools, the use of light sources, such as the light-emitting diode (LED), is a promising mean to seek increased cytokine proliferation, adhesion, survival and secretion, with the aim of improving the quality of treatment. Based on studies that show a temporary effect by the LED on cells, the purpose of this study is to irradiate MSCs with LED and analyze the duration of its effect, in order to find the best post-irradiation period for the use of the cells.