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The relationship between bone, fat and muscle tissues in patients with X Linked Hypophosphatemic Rickets (XLHR)

Grant number: 21/01475-9
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): April 01, 2021
Effective date (End): March 31, 2024
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal researcher:Francisco José Albuquerque de Paula
Grantee:Maisa Monseff Rodrigues da Silva
Home Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Associated research grant:18/18071-5 - Hydroelectrolytic and energy homeostasis: from cellular metabolism to endocrine systems in different phases of development, AP.TEM


X-Linked Hypophosphatemic Rickets (RHLX) is the most common form of genetic Rickets, with an increase in the circulating rate of FGF23 and consequent phosphaturia and Hypophosphatemia. The consequences of chronic Hypophosphatemia have already been well established regarding bone damage. Using a convenience sample from the HCFMRP-USP Osteometabolism Outpatient Clinic, we will evaluate the impact of this deficiency on energy and muscle metabolism - not yet studied - and its interaction from an endocrinological point of view (bone, muscle and fat tissues). (AU)

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