Development and application of simple and rapid analytical methods for the determination of endocrine disruptors and oxidative stress biomarkers in biological samples for evaluation of exposure of children and pregnant women

• Grant number: 21/03633-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2021
• End date: June 30, 2022
• Field of knowledge: Health Sciences - Pharmacy - Toxicological Analysis
• Principal Investigator: Fernando Barbosa Júnior
• Grantee: Bruno Alves Rocha
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health, AP.TEM

Abstract

The increasing demand for consumer goods and industrialized products, such as personal care products, food and pharmaceuticals, has led to an accumulation of chemical compounds in the environment and exposing man to emerging contaminants, among which are the Endocrine Disruptores (ED). Therefore, issues related to environmental contamination and human exposure to this class of contaminants have become one of the main points of discussion among scientific communities and regulatory agencies around the world. The execution of studies related to biomonitoring of human exposure to DEs is extremely important, since some of these may be associated with several health problems, including Cancer, Diabetes and Endometriosis. Although several countries are already continuously developing biomonitoring studies of their populations, in Brazil these studies are still limited and little is known about the levels of exposure to endocrine disruptors. In this sense, the present proposal aims to determine urinary biomarkers to assess exposure to EDs in children and pregnant women living in the Country and their possible associations with oxidative stress biomarkers through the development and application of simple and rapid analytical methods. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ROCHA, BRUNO A.; CESILA, CIBELE A.; MARTINS, AIRTON C.; SOUZA, MARILIA C. O.; BARBOSA JR, FERNANDO. Validation and Application of a Methodology for Quantifying Levels of Parabens in Sports Supplements from Brazil Using Liquid Chromatography-Mass Spectrometry. Journal of the Brazilian Chemical Society, DEC 2021. (18/24069-3, 21/03633-0)

OLIVEIRA SOUZA, MARILIA CRISTINA; DEVOZ, PAULA PICOLI; BIANCHI XIMENEZ, JOAO PAULO; BOCATO, MARIANA ZUCCHERATO; ROCHA, BRUNO ALVES; BARBOSA, FERNANDO. Potential Health Risk to Brazilian Infants by Polybrominated Diphenyl Ethers Exposure via Breast Milk Intake. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 19, n. 17, p. 11-pg., 2022-09-01. (21/07994-8, 18/24069-3, 15/19665-8, 21/03633-0, 19/07161-6)

OLIVEIRA SOUZA, MARILIA CRISTINA; ROCHA, BRUNO ALVES; BIANCHI XIMENEZ, JOAO PAULO; DEVOZ, PAULA PICOLI; SANTANA, ANTHONY; CAMPIGLIA, ANDRES DOBAL; BARBOSA JR, FERNANDO. Urinary levels of monohydroxylated polycyclic aromatic hydrocarbons in Brazilian children and health risk assessment: a human biomonitoring-based study. Environmental Science and Pollution Research, v. 29, n. 31, p. 12-pg., 2022-02-18. (18/24069-3, 19/07161-6, 21/03633-0)

ACUNHA, TANIZE; ROCHA, BRUNO ALVES; NARDINI, VIVIANI; BARBOSA JR, FERNANDO; FACCIOLI, LUCIA HELENA. Lipidomic profiling of the Brazilian yellow scorpion venom: new insights into inflammatory responses following Tityus serrulatus envenomation. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, v. 86, n. 9, p. 13-pg., 2023-03-11. (15/00658-1, 21/03633-0, 18/24069-3, 14/07125-6, 22/07979-1, 18/25704-4)

ROCHA, BRUNO ALVES; GALLIMBERTI, MATHEUS; XIMENEZ, JOAO PAULO BIANCHI; BASSO, CARLA GIOVANA; MARTINO-ANDRADE, ANDERSON JOEL; KOCH, HOLGER MARTIN; CALIXTO, LEANDRO AUGUSTO; BARBOSA, FERNANDO. An eco-friendly sample preparation procedure based on air-assisted liquid-liquid microextraction for the rapid determination of phthalate metabolites in urine samples by liquid chromatography-tandem mass spectrometry. Talanta, v. 266, p. 10-pg., 2024-01-01. (22/07979-1, 21/03633-0, 18/24069-3, 20/02939-6)