Effects of exercise training associated with protein supplementation on bone parameters in older people with sarcopenic obesity under caloric restriction: a randomized controlled clinical trial

• Grant number: 20/07540-4
• Support type: Scholarships in Brazil - Doctorate
• Effective date (Start): July 01, 2021
• Effective date (End): June 30, 2025
• Field of knowledge: Health Sciences - Physical Education
• Principal researcher: Hamilton Augusto Roschel da Silva
• Grantee: Gersiel Nascimento de Oliveira Júnior
• Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The decline in bone content and/or integrity is an inherent process of aging. However, some comorbidities may exacerbate this losses. For instance, the association of sarcopenia and obesity (i.e. sarcopenic obesity) can potentiate these effects. In this regard, although caloric restriction is the standard intervention to manage body weight, it may also promote loss of bone, emphasizing the necessity of other complementary strategies. Muscle strengthening combined with aerobic training is thought as an important countermeasure to attenuate the decline in bone and muscle mass during weight loss. However, this strategy is not able to fully reverse these declines, thus, warranting complementary strategies. Due to the role of protein in bone tissue, it has been suggested that protein supplementation could contribute to mitigate bone loss. However, the role of protein supplementation plus exercise on bone mass in sarcopenic obesity undergoing caloric restriction is lacking. Thus, the aim of this project is investigate whether the protein supplementation promote additional effect to combined training on bone tissue in sarcopenic obese older adults undergoing caloric restriction. 60 sarcopenic obese older adults will be randomized into 3 groups: 1) combined training plus protein supplementation and caloric restriction (n=20); 2) combined training plus placebo supplementation and caloric restriction (n=20) and 3) control group (non-exercise) (n=20). The bone parameters (bone mineral content and density, bone microarchitecture and biomarkers od bone remodeling) will evaluated before and after 16 weeks of intervention. To compare the effects of intervention will be used mixed-model of repeated measures.