Mapping epigenomic signatures associated with IDH mutation

• Grant number: 21/08190-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: September 01, 2021
• End date: July 31, 2022
• Field of knowledge: Health Sciences - Medicine - Medical Clinics
• Principal Investigator: Tathiane Maistro Malta Pereira
• Grantee: Isabela Dias Erthal
• Host Institution: Faculdade de Ciências Farmacêuticas de Ribeirão Preto (FCFRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 18/00583-0 - Integrative epigenomic analysis of gliomas: defining regulatory regions associated with stemness and with the hypermethylator phenotype of IDH1/2 mutant tumors, AP.JP

Abstract

This fellow will work on the identification of epigenomic alteration in tumor samples harboring IDH1/2 mutation. This person will use public data and open source R/bioconductor tools to map the shared and/or tissue-specific epigenetic changes associated with mutations in IDH1/2 genes across different tumor types. This study will contribute to uncovering the mechanisms that lead to the deregulation of global DNA methylation and its clinical implications. AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LARISSA MIYUKI OKANO; LÍVIA MARIA MACIEL DA FONSECA; ISABELA DIAS ERTHAL; TATHIANE MAISTRO MALTA. Epigenomic integrative analysis pinpoint master regulator transcription factors associated with tumorigenesis in squamous cell carcinoma of oral tongue. GENETICS AND MOLECULAR BIOLOGY, v. 46, n. 2, 2023-06-19. (19/14928-1, 18/00583-0, 21/08190-0)