Nanostructures enriched with vegetable oils for optimization of formulation with model drugs

• Grant number: 21/00319-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: October 01, 2021
• End date: February 29, 2024
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Priscila Gava Mazzola
• Grantee: Julia Cedran Coco
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 22/00931-3 - Foamable microemulsions for antifungal drug delivery, BE.EP.MS

Abstract

New release systems with permeation promoters for topical delivery are needed for the treatment of persistent diseases, where oral therapy causes adverse effects. Liposomes are promoters of biocompatible permeation and are successful on the market, but have the limitation of being subject to the oxidation of lipid membranes. Vegetable oils such as baru (Dipteryx alata Vog.) and chia (Salvia hispanica L.) are rich in antioxidant compounds such as polyphenols, tocopherols and triterpenes, in addition to unsaturated fatty acids and triacylglycerides with possible healing activity. Our hypothesis is that these vegetable oils could increase the stability of liposomes through protection against oxidation, in addition to creating a multifunctional delivery system, with synergistic therapeutic benefits, increased permeation of the active and adding beneficial effects to the final formulation, such as healing activity. The delivery of nystatin, an antifungal drug with difficulty in formulating due to lipophilicity, could be optimized by this new delivery system for the treatment of persistent fungal diseases. Thus, the objectives of the study are (i) to extract and characterize the oils from the baru nut and chia seed; (ii) producing liposomes enriched with baru or chia oils; (iii) incorporating nystatin to the enriched liposomes; (iv) characterize the liposomes in terms of mean diameter, size distribution, morphology, encapsulation efficiency and nystatin release and (v) evaluate the permeation, antifungal and healing activity of the final formulations. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SUEIRO, ANA CLAUDIA; DOS SANTOS, ERICA MENDES; TUNDISI, LOUISE LACALENDOLA; MASQUETTI FAVA, ANA LAURA; LUNA SILVERIO, LUIZA APARECIDA; COCO, JULIA CEDRAN; ATAIDE, JANAINA ARTEM; PAIVA-SANTOS, ANA CLAUDIA; MAZZOLA, PRISCILA GAVA. Transdermal delivery systems for migraine treatment: A gap to explore. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 77, p. 8-pg., 2022-11-02. (18/06475-4, 18/07707-6, 21/00319-3, 20/11333-4)

SILVERIO, LUIZA APARECIDA LUNA; COCO, JULIA CEDRAN; DE MACEDO, LUCAS MALVEZZI; DOS SANTOS, ERICA MENDES; SUEIRO, ANA CLAUDIA; ATAIDE, JANAINA ARTEM; TAVARES, GUILHERME DINIZ; PAIVA-SANTOS, ANA CLAUDIA; MAZZOLA, PRISCILA GAVA. Natural product-based excipients for topical green formulations. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 33, p. 18-pg., 2023-06-03. (18/06475-4, 18/07707-6, 21/00319-3, 20/11333-4)

DE CASTRO, KARINE CAPPUCCIO; COCO, JULIA CEDRAN; DOS SANTOS, ERICA MENDES; ATAIDE, JANAINA ARTEM; MARTINEZ, RENATA MILIANI; MONTEIRO DO NASCIMENTO, MONICA HELENA; PRATA, JOAO; LOPES DA FONTE, PEDRO RICARDO MARTINS; SEVERINO, PATRICIA; MAZZOLA, PRISCILA GAVA; et al. Pluronic (R) triblock copolymer-based nanoformulations for cancer therapy: A 10-year overview. JOURNAL OF CONTROLLED RELEASE, v. 353, p. 21-pg., 2022-12-17. (18/10799-0, 20/03727-2, 21/00319-3, 19/20303-4, 20/11333-4, 18/06475-4, 19/16169-0, 18/07707-6, 17/10789-1, 19/08549-8)

DOS SANTOS, ERICA MENDES; ATAIDE, JANAINA ARTEM; COCO, JULIA CEDRAN; MASQUETTI FAVA, ANA LAURA; LUNA SILVERIO, LUIZA APARECIDA; SUEIRO, ANA CLAUDIA; ALVES SILVA, JESSICA RIBEIRO; LOPES, ANDRE MORENI; PAIVA-SANTOS, ANA CLAUDIA; MAZZOLA, PRISCILA GAVA. Spondias sp: Shedding Light on Its Vast Pharmaceutical Potential. Molecules, v. 28, n. 4, p. 16-pg., 2023-02-01. (20/11333-4, 18/07707-6, 21/00319-3, 18/10799-0, 18/06475-4, 17/10789-1)