Magnetoliposomes for remote controlled drug release, activated through the application of an alternating magnetic field

• Grant number: 21/13592-0
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: January 01, 2022
• End date: April 30, 2024
• Field of knowledge: Physical Sciences and Mathematics - Physics - Condensed Matter Physics
• Principal Investigator: Kleber Roberto Pirota
• Grantee: Adriele Aparecida de Almeida
• Host Institution: Instituto de Física Gleb Wataghin (IFGW). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 17/10581-1 - Emergent phenomena in reduced dimension systems, AP.ESP

Abstract

Design of a drug carrier, based on liposomes with the presence of magnetic nanoparticles (NP). This unique combination was demonstrated to achieve drug targeting, with controlled drug release in specific tissues, under the application of an external magnetic field. The first part of the project is focused on the synthesis of the nanostructures itself. Being essential to determine the impact of different NP spatial distribution, in addition to the magnetic interactions present on the system formation. Imperative to perform structural, magnetic and colloidal characterization of the system.Magnetoliposomes shall be evaluated in-vitro with cells derived from human papillary carcinoma to establish their cytotoxicity limits. Drug encapsulation followed by magnetic hyperthermia treatment, by application of an alternating magnetic field to the system. A thorough study about the magnetoliposomes structure, morphology, stability, permeability, toxicity and biodistribution is necessary. This thorough study is the objective of this postdoc project.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DIOGO, EMILAY B. T.; DA SILVA, EUFRANIO N.; OLIVEIRA, WILLIAN X. C.; STUMPF, HUMBERTO O.; FABRIS, FERNANDO; DE ALMEIDA, ADRIELE A.; KNOBEL, MARCELO; FERREIRA, FABIO F.; NUNES, WALLACE C.; PEDROSO, EMERSON F.; et al. Isostructural Oxamate Complexes with Visible Luminescence (Eu³⁺) and Field-Induced Single-Molecule Magnet (Nd³⁺). CHEMISTRY-AN ASIAN JOURNAL, v. N/A, p. 13-pg., 2024-10-31. (21/13592-0, 23/09820-2, 17/10581-1)

FABRIS, FERNANDO; ALMEIDA, ADRIELE A.; RIBEIRO, PABLO RAFAEL TRAJANO; PIROTA, KLEBER ROBERTO; MURACA, DIEGO. Magnetic properties and dipolar interactions of Fe₃O₄ nanoparticle clusters produced by bottom-up self-assembly. JOURNAL OF MATERIALS CHEMISTRY C, v. N/A, p. 12-pg., 2025-04-14. (22/16460-0, 19/13678-1, 17/10581-1, 21/13592-0)

OROZCO-HENAO, JUAN M.; ALMEIDA, ADRIELE A.; FABRIS, FERNANDO; FLORIDIA ADDATO, MARIA A.; FONTICELLI, MARIANO H.; MURACA, DIEGO; LAVORATO, GABRIEL C.. Engineering Graded Magnetic Anisotropy via Cation Interdiffusion in Core/Shell Nanoparticles. Nano Letters, v. 25, n. 33, p. 8-pg., 2025-08-08. (21/13592-0, 22/16460-0, 19/13678-1)

DA SILVEIRA, CLEVERTON O. C.; OLIVEIRA, WILLIAN X. C.; DA SILVA, EUFRANIO N.; ALVARENGA, MEIRY E.; MARTINS, FELIPE T.; GATTO, CLAUDIA C.; PINHEIRO, CARLOS B.; PEDROSO, EMERSON F.; SILVA, JULIA P. O.; MARQUES, LIPPY F.; et al. Photoluminescence and magnetic properties of isostructural europium(III), gadolinium(III) and terbium(III) oxamate-based coordination polymers. DALTON TRANSACTIONS, v. 53, n. 36, p. 16-pg., 2024-07-17. (21/13592-0)