| Grant number: | 21/03265-1 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | January 01, 2022 |
| End date: | December 31, 2026 |
| Field of knowledge: | Agronomical Sciences - Animal Husbandry - Animal Production |
| Principal Investigator: | Miguel Henrique de Almeida Santana |
| Grantee: | Guilherme Henrique Gebim Polizel |
| Host Institution: | Faculdade de Zootecnia e Engenharia de Alimentos (FZEA). Universidade de São Paulo (USP). Pirassununga , SP, Brazil |
| Associated research grant: | 17/12105-2 - Fenomics of fetal programming effects on beef cattle production: a systemic approach, AP.JP |
| Associated scholarship(s): | 23/09113-4 - Integration of multi-omics functional information to better understand the fetal programming effects on bulls, BE.EP.DR |
Abstract Systems biology is the field that studies the interactions between components of a biological system in a holistic way, however it is still little explored in science due to the difficulty of integrating data from different molecular levels. It is already known that the nutrition of pregnant mothers in livestock is an extrinsic factor that can interfere with characteristics of productive interest throughout the life of the offspring, however the mechanisms related to the effects of this highly complex process still require studies. This project seeks to elucidate part of the mechanisms for multiomic and tissue integration in male Nellore animals that have been identified with different prenatal supplementation strategies. This study will be based on 63 animals from 3 different nutritional prenatal treatments: NP - only mineral supplementation (common to all treatments), PP - protein-energy supplementation in the final third of pregnancy and PC - protein-energy supplementation throughout the gestation. This project is divided into 3 studies. In study 1, a multi-omic approach of liver from selected animals will be carried out. The differential expression and co-expression networks of the genes will be evaluated by transcriptomics. The metabolites present in that organ will be evaluated by the metabolomics. These data will integrate with genomic data of 35 thousand single nucleotide polymorphisms (SNPs) to relate to the performance of these bulls. In study 2, the systems biology approach using differential expression and gene co-expression networks in the liver and skeletal muscle of bulls will be carried out by transcriptomics, the profile of metabolites in plasma, meat, subcutaneous fat and liver will be evaluated by metabolomics and profile of ruminal microbial communities will be evaluated by metagenomics. In this study, fetal programming will be associated with multi-tissue transcriptomics and multi-tissue metabolomics and the integration of omics, tissues and phenotypes of bulls from birth to slaughter. This project may demonstrate the biological basis of the influence of fetal programming on the performance of Nellore animals. (AU) | |
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