Evaluation of antimicrobial activity of bioceramics against multidrug-resistant strains

• Grant number: 21/13122-3
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2022
• End date: January 31, 2023
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Paola Castro Moraes
• Grantee: Mariana Bugov
• Host Institution: Faculdade de Ciências Agrárias e Veterinárias (FCAV). Universidade Estadual Paulista (UNESP). Campus de Jaboticabal. Jaboticabal , SP, Brazil

Abstract

Several bioceramics are developed and applied in animal models to obtain faster bone repair, such as calcium phosphate cements and biopolymers. However, postoperative infections of the implanted area inevitably lead to the resorption of much of the implant or its total loss by microbial colonization and biofilm formation on the surface of bioceramics. Widespread use of antimicrobials for several decades has led to an increased prevalence of multidrug-resistant bacteria, challenging our ability to treat bacterial infections. Some bioceramic formulations have antibacterial properties because they damage bacterial structures and walls. This work aims to evaluate the antimicrobial activity of four different bioceramic formulations (Porous Synthetic Hydroxyapatite, Lumina-Bone®, bioglass 45S5 and boro-silicate bioglass) against multidrug-resistant microorganisms commonly involved in surgical site infection by conducting microdilution susceptibility test in broth.