Monitoring of pro-inflammatory cytokines in dogs with Chronic Kidney Disease in Uremic Syndrome submitted to two different intermittent hemodialysis approaches

• Grant number: 21/03964-7
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: April 01, 2022
• End date: August 31, 2023
• Field of knowledge: Agronomical Sciences - Veterinary Medicine - Animal Clinics and Surgery
• Principal Investigator: Priscylla Tatiana Chalfun Guimaraes-Okamoto
• Grantee: Suellen Rodrigues Maia
• Host Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

Dialytic modality increasingly studied and applied to veterinary patients, intermittent hemodialysis (HDI) has now become a more accessible alternative in the management of dogs and cats that suffer from dialysable conditions, among which the removal of drugs, intoxications stands out, electrolyte disturbances, hyperhydration, and acute and chronic nephropathies. However, the evaluation of pro-inflammatory cytokines, both derived from this therapy and those possibly dialyzed by it, remains unclear in this scenario. The objective is to evaluate the dynamics of proinflammatory cytokines (IL-1², IL-6, and TFN-±) in Chronic Kidney Sick dogs in Uremic Syndrome submitted to different HDI techniques (conventional and by-pass), comparing the results after hemodialysis with those previously obtained Eighteen dogs with Chronic Kidney Disease in Uremic Syndrome will be selected and divided into two groups: nine animals will compose the group submitted to traditional HDI (GHT) and nine animals the group submitted to HDI by the bypass (GHB). Nine healthy dogs will make up the Control Group (CG). Laboratory assessments (serum and urinary) will be carried out in advance and also after the dialysis treatment, which will consist of the assessment of three sessions (S1, S2, and S3) of HDI. Control group animals will have blood and urine collections only at the beginning of the study. Also, all animals included will be assessed for their clinical condition during the study period. It is hypothesized that, just like in medicine, dogs submitted to HDI may experience an increase in pro-inflammatory cytokines resulting from this therapy, and that there may be differences according to the approach used, this condition being likely to cause an increase in morbidity and worsening the quality of life of these animals. (AU)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

MAIA, Suellen Rodrigues. Pro-inflammatory cytokines in dogs with chronic kidney disease in uremic syndrome undergoing intermittent hemodialysis with and without bypass. 2023. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária e Zootecnia. Botucatu Botucatu.