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| Author(s): |
Suellen Rodrigues Maia
Total Authors: 1
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| Document type: | Doctoral Thesis |
| Press: | Botucatu. 2023-08-30. |
| Institution: | Universidade Estadual Paulista (Unesp). Faculdade de Medicina Veterinária e Zootecnia. Botucatu |
| Defense date: | 2023-08-16 |
| Advisor: | Priscylla Tatiana Chalfun Guimarães Okamoto |
| Abstract | |
Intermittent hemodialysis (IH) has become a viable and accessible therapy for dogs with acute and chronic nephropathies. However, evaluating pro-inflammatory cytokines, potentially derived from this therapy, remains unclear. The objective was to evaluate the dynamics of pro-inflammatory cytokines (IL-1β, IL-6, and TFN-α) in dogs with chronic kidney disease in uremic syndrome submitted to different IH approaches (with and without bypass). Eight dogs with chronic kidney disease in uremic syndrome were selected and allocated into two groups: IH without bypass (IH group) and IH with bypass (IH + bypass group). Four healthy dogs made up the control group (CG). Laboratory evaluations were performed before, during, and after the first IH session. Comparative analyses between each group and evaluation moment were applied, as well as a global comparison of cytokines (median of all results obtained) between groups. There were no significant alterations in the studied cytokines between the evaluation moments of the groups of dogs submitted to IH. The IL-1β concentration was higher after the session in the IH group compared to the CG. The comparison of the global concentration revealed a higher concentration of IL-1β and TNF-α in the CKD groups when compared to the CG, and the IH group also had a higher IL-6 value. Higher concentrations of IL-1β and IL-6 were also observed in IH group compared to IH + bypass group. The animals submitted to IH, regardless of the group, had lower urea and creatinine levels after the procedure, as well as improved acidemia. Session-related data demonstrated that both approaches were effective and safe. In conclusion, a single session of IH, with or without bypass, did not increase the concentrations of pro-inflammatory cytokines in dogs with chronic kidney disease, however, it contributed to the maintenance of the inflammatory state, in addition, dogs submitted to IH without bypass demonstrated higher concentrations of the studied cytokines. (AU) | |
| FAPESP's process: | 21/03964-7 - Monitoring of pro-inflammatory cytokines in dogs with Chronic Kidney Disease in Uremic Syndrome submitted to two different intermittent hemodialysis approaches |
| Grantee: | Suellen Rodrigues Maia |
| Support Opportunities: | Scholarships in Brazil - Doctorate |