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Study of the influence of the morphological properties of SBA-15 on the efficacy of molecules with therapeutic potential and vaccines

Grant number: 22/08360-5
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): September 01, 2022
Effective date (End): December 31, 2023
Field of knowledge:Biological Sciences - Immunology - Immunochemistry
Principal Investigator:Tereza da Silva Martins
Grantee:Matheus Carlos Romeiro Miranda
Host Institution: Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil
Associated research grant:17/17844-8 - Nanostructured silica as a protective vehicle for vaccines and biomolecules, AP.TEM


Ordered mesoporous silicas, due to their structural, textural and morphological properties, such as highly ordered periodic porous structure, high specific surface area and pore size that can vary from 2 to 50 nm, and particles with size that can varies from micrometer to nanometer scale, have been extensively studied and are promising for several applications, mainly biomedical applications, in the immunological area, as adjuvants/vehicles for the production of oral vaccines. Accordingly, this research project aims to synthesize and characterize ordered mesoporous silicas, type SBA-15, with different morphologies, particle size and porosity for incorporating vaccine antigens, aiming at the development of oral vaccines for diphtheria and tetanus. Silicas with different particle sizes and morphologies will be synthesized by various synthesis conditions, such as, synthesis temperature, agitation, pH, time of hydrothermal treatment and solvent. The silicas obtained will be characterized by small angle X-ray scattering, Fourier transform infrared spectroscopy, nitrogen physisorption isotherms, scanning electron microscopy, transmission electron microscope and thermal analysis. The vaccine antigens and the molecules with therapeutic potential will be incorporated into the silicas by incipient wetness impregnation method, in a buffer solution, and the hybrid materials obtained will be characterized by various physical-chemical techniques and then safety and efficacy tests, as oral vaccines, will be performed.

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