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Effects of Carbetocin on ethanol behavioral sensitization and glucocorticoid receptors in female and male Swiss mice

Grant number: 22/05101-9
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): August 01, 2022
Effective date (End): July 31, 2023
Field of knowledge:Biological Sciences - Pharmacology - Neuropsychopharmacology
Principal Investigator:Rosana Camarini
Grantee:Beatriz Costa Vieira de Souza
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Substance use disorder is a complex disease, influenced by genetic, environmental, and social factors (Kendler, 2001), and is characterized by the compulsive use of a drug, loss of control over its administration, and persistent use despite its negative effects (Koob, 2008). Oxytocin (OT) is a pro-social peptide that has been increasingly described as a protector against drug addiction. Specifically, regarding ethanol, it has been previously shown that OT decreases self-administration (Leong et al., 2018), blocks motor impairment (Bowen et al., 2015) in rodents, and decreases craving in humans (Hansson et al., 2018). Glucocorticoids have been implicated in the regulation of OT. The aim of this work is to evaluate the effects of Carbetocin (CBT), an OT analog, in the expression of behavioral sensitization to ethanol, in plasma corticosterone levels, and in the expression of glucocorticoid receptors (GR) in male and female mice.(AU)

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