Interaction of pathogenic microorganisms that trigger brain pathologies, specifically Trypanosoma vivax, Zika Virus and SARS-CoV-2 with experimental hosts

• Grant number: 22/08342-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: August 01, 2022
• End date: May 31, 2025
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Paola Marcella Camargo Minoprio
• Grantee: Gabriela Prado Paludo
• Host Institution: Institut Pasteur de São Paulo (IPSP). São Paulo , SP, Brazil
• Associated research grant: 17/27131-9 - Integrated strategy for the study of infectious agents causing emerging and/or neglected diseases transmitted by vectors of global impact, AP.TEM

Abstract

The fellow will study in experimental hosts the interaction of animal and/or human pathogenic microorganisms that trigger brain pathologies. "Wild" microorganisms or microorganisms carrying genes for luminescence/fluorescence will be used for analysis of infectious processes through non-invasive real-time imaging. The fellow will participate in associated sub-projects that utilize ZIKV and SARS-Cov-2 viruses.The fellow will adapt cultures of the parasite Trypanosoma vivax (PLoS Negl Trop Dis. 2011 Dec;5(12):e1461) for further study of the in vivo (immuno)inflammatory process and its consequences in the impairment of the brain and blood-brain barriers, using immunology techniques and 2D- and 3D- imaging, under NB2 and NB3 confinement conditions. (AU)