Extraction of Biological Information from Topological Measurements of Networks

• Grant number: 22/06218-7
• Support Opportunities: Scholarships in Brazil - Master
• Start date: September 01, 2022
• End date: August 31, 2023
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: Odemir Martinez Bruno
• Grantee: João Paulo Cassucci dos Santos
• Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated research grant: 18/22214-6 - Towards a convergence of technologies: from sensing and biosensing to information visualization and machine learning for data analysis in clinical diagnosis, AP.TEM

Abstract

The objective of this project is to use metabolic networks built from experiments of gene expression as to obtain possible differentially expressed metabolic pathways, so we can better comprehend the workings of the metabolism of the fungus Aspergillus fumigatus, that has been acquiring resistance to fungicides like Caspofungin. The construction of the networks will use algorithms already described in the literature as valid for the obtention of metabolic pathways in other organisms. Topological patterns in these networks that can allow us to comprehend and classify them based on biological functions will be searched.

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SANTOS, João Paulo Cassucci dos. Systems biology and machine learning: new applications of computational methods. 2024. Master's Dissertation - Universidade de São Paulo (USP). Instituto de Física de São Carlos (IFSC/BT) São Carlos.