Molecular imaging by magnetoacoustography using functionalized magnetic nanoparticles

• Grant number: 22/12771-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: October 01, 2022
• Status: Discontinued
• Field of knowledge: Engineering - Biomedical Engineering - Medical Engineering
• Principal Investigator: Antonio Adilton Oliveira Carneiro
• Grantee: Ariane Franson Sanches
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Associated research grant: 18/16939-8 - Development and implementation of novel acoustic, magnetic and optical techniques for diagnostic and therapeutic applications, AP.TEM
• Associated scholarship(s): 24/22214-7 - Integration of Magnetomotive Ultrasound, Ultrafast Ultrasound Imaging and Ultrasound Localization Microscopy, BE.EP.DD

Abstract

Advances in the study of nanostructures have allowed their application in the most diverse areas, especially in Medicine to aid diagnosis and treatment. Among these applications is the detection of anomalies at the molecular level, which are of great importance for the early diagnosis of diseases. In this context, nanoparticles can be used as contrast in functional ultrasound and MRI images, which have the advantage of not using ionizing radiation. The nanoparticles work as tracers, which are functionalized with some type of ligand, for example, an antibody, which promotes the accumulation of molecular targets when placed in contact with the pathological region. The reading of this accumulation of a particular molecule in the biosensor element is done using physical techniques, such as reading the variation of electrical conductivity, microscopic image, among others. In this project, we intend to use magnetic fields for the excitation of nanoparticles, which will be functionalized for accumulation in cancerous tissues, then measuring the shear waves that allow the quantification of the viscosity of the medium, implementing a platform that contains other functionalities, such as Elastographic and thermal measurements of tissues. The addition of viscosity quantification will allow a study of the correlation between the temperatures reached by the agitation of the nanoparticles and the change in the biomechanical characteristics of the tissue. Thus, the studies involving molecular images in this project have as main objective the development of new technologies for applications in the diagnosis and treatment of cancerous tissues. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COLLAZOS-BURBANO, DAVID A.; FREIRE, JOSE E.; SANCHES, ARIANE F.; ZUFELATO, NICHOLAS; ULIANA, JOAO H.; BRASSESCO, MARIA S.; CARNEIRO, ANTONIO A. O.; PAVAN, THEO Z.. Beyond Axial Symmetry: Tracking Vectorial Motion Enhances Nanoparticles Mapping With Magnetomotive Ultrasound. IEEE ACCESS, v. 13, p. 13-pg., 2025-01-01. (21/06728-2, 23/11602-3, 18/16939-8, 23/04056-2, 22/01470-0, 22/12771-0, 23/04057-9)