Development and implementation of novel acoustic, magnetic and optical techniques for diagnostic and therapeutic applications

• Grant number: 18/16939-8
• Support Opportunities: Research Projects - Thematic Grants
• Start date: June 01, 2022
• End date: May 31, 2027
• Field of knowledge: Engineering - Biomedical Engineering - Bioengineering
• Principal Investigator: Antonio Adilton Oliveira Carneiro
• Grantee: Antonio Adilton Oliveira Carneiro
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Pesquisadores principais: José Ricardo de Arruda Miranda ; Theo Zeferino Pavan
• Associated researchers: Ana Paula Ramos ; Antônio Carlos Shimano ; Eduardo Tavares Costa ; Elaine Caldeira de Oliveira Guirro ; George Cunha Cardoso ; Jorge Elias Júnior ; Koiti Araki ; Laudemir Carlos Varanda ; Luiz Otavio Murta Junior ; Marcello Henrique Nogueira Barbosa ; María Sol Brassesco Annichini ; Oswaldo Baffa Filho ; Renata Fonseca Vianna Lopez ; Rinaldo Roberto de Jesus Guirro ; Tito José Bonagamba
• Associated research grant(s): 22/07463-5 - Multi-user equipment approved in grant 2018/16939-8: equipment of ultrasound for reasearch model VANTANGE 256 from Verasonics, AP.EMU
• Associated scholarship(s): 23/18170-1 - Strategies for functionalization of magnetic nanoparticles for oral delivery evaluated by biomagnetic techniques, BP.MS; 23/09199-6 - Elastographic analysis of muscle tissue in healthy subjects after interaction with thermal resources., BP.MS; 24/00557-0 - Integrating nanotechnology, magnetism, light, and sound to innovate in clinical diagnosis and therapy., BP.JC; + associated scholarships 24/00558-6 - Integrating nanotechnology, magnetism, light, and sound to innovate in clinical diagnosis and therapy, BP.JC; 23/13435-7 - "Construction and characterization of a focused ultrasound transducer for Neuromodulation.", BP.IC; 23/15548-3 - Biological tissue mimicker using ex-egg chicken embryos for magnetic and acoustic measurements., BP.IC; 23/11602-3 - Drug Delivery to Keratinocytes and Caco-2 Cells via Ultrasound-Assisted Magnetic Nanoparticles., BP.PD; 23/11205-4 - FEASIBILITY STUDY OF A PROTOTYPE ENTERAL TUBE DEVELOPED BY MEANS OF THE MAGNETO-ACOUSTOGRAPHY TECHNIQUE COUPLED TO ULTRASOUND, BP.IC; 23/09165-4 - Study on Samples of Bones by Acoustography, BP.IC; 23/03371-1 - Magnetic hyperthermia guided by molecular and thermal images, BP.PD; 23/07837-5 - Implementation of an ultrasonic platform for generating 3D elastographic images of the breast, BP.DD; 23/04056-2 - Implementation and characterization of a theranostic platform through the integration of a programmable ultrasound platform with magnetic and optical excitation modules, BP.TT; 23/05357-6 - Characterization of magnetic nanoparticles as image contrast by ultrasound, BP.IC; 22/12028-6 - Biological tissue mimicry for magnetoacoustography measurements, BP.IC; 22/12771-0 - Molecular imaging by magnetoacoustography using functionalized magnetic nanoparticles, BP.DD - associated scholarships

Abstract

Scientific and technological advances in biomedical transducers are providing the development of new hybrid platforms for diagnostic and therapy. These hybrid technologies are also called theranostic systems. The Group of Innovation in Medical Instrumentation and Ultrasound (GIIMUS) of USP at Ribeirão Preto, in collaboration with other national and international centers, has explored new ultrasonic technologies in combination with other magnetic and optical techniques for application in biomedicine. For example, when a medium is labeled with magnetic nanoparticles and submitted to an external oscillating magnetic field, it will be magnetized generating low amplitude mechanical vibration due to the magnetic force between the external field and the magnetization of the nanoparticles. In this case, the location of the nanoparticles and the mechanical properties of this medium can be diagnosed using magnetic susceptibility measurements and ultrasonic elastography techniques. In addition, the same medium may be heated for therapeutic purposes also using an oscillating external magnetic field and / or high-power ultrasonic radiation. To map the temperature variation of the internal structures of the tissue, and ultrasound system can be used. Likewise, if a medium is excited with pulsed light, it will be absorbed and mechanical waves will be generated due to the thermoelastic effect. These pressure waves can be detected using ultrasonic transducers configured only as acoustic receivers. The main goals to be developed in this project will be: 1 - Implementation of new ultrasound elastographic techniques on a dedicated programmable Ultrasound platform (Verasonics ®); 2 - Development and application of theranostic platforms using light and magnetism to generate mechanical disturbances of the internal structures of tissues marked with functionalized nanoparticles and diagnosis of the viscoelastic and thermal properties of these structures by ultrasonic methods; 3 - Application of a hybrid transducer composed of magnetic susceptometry and ultrasound for the study of pharmacokinetics in animal models marked with functionalized magnetic nanoparticles; 4 - Studies of bone microstructures using high frequency (MHz) ultrasonic radiation forces and detection of low frequency acoustic radiation. (AU)

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ARSALANI, SAEIDEH; HADADIAN, YASER; MAZON, ERNESTO E.; GUIDELLI, EDER J.; KAVA, EMANUEL; RAMOS, ANA PAULA; GAULDI, ALEXANDRE JOSE; PAVAN, THEO Z.; BAFFA, OSWALDO; CARNEIRO, ANTONIO A. O.. Uniform size PEGylated iron oxide nanoparticles as a potential theranostic agent synthesized by a simple optimized coprecipitation route. Journal of Magnetism and Magnetic Materials, v. 564, p. 10-pg., 2022-10-29. (18/16939-8, 13/07699-0)

ULIANA, JOAO HENRIQUE; THOMAZ SAMPAIO, DIEGO RONALDO; SANCHES, ARIANE FRANSON; PAVAN, THEO ZEFERINO; DE OLIVEIRA CARNEIRO, ANTONIO ADILTON. MUSA-WAVE: A Software Platform for Magnetomotive Ultrasound and Shear Wave Analysis. 2024 IEEE UFFC LATIN AMERICA ULTRASONICS SYMPOSIUM, LAUS, v. N/A, p. 4-pg., 2024-01-01. (22/07463-5, 21/06728-2, 18/16939-8)

ULIANA, JOAO H.; BRAZ, GUILHERME A.; OLIVEIRA, EVERTON L.; ARAUJO-FERREIRA, ARTHUR G.; MORAIS, MATEUS M.; TREVIZAN, WILLIAN A.; FORTULAN, CARLOS A.; BONAGAMBA, TITO J.; PAVAN, THEO Z.; CARNEIRO, ANTONIO A. O.. Investigation of rock porosity using vibroacoustography. Journal of the Brazilian Society of Mechanical Sciences and Engineering, v. 46, n. 10, p. 11-pg., 2024-10-01. (09/54880-6, 18/16939-8, 20/00010-0)

DE LIMA, VANESSA F.; BACHOUR, RAQUEL P. DE SOUZA; CARDOSO, GEORGE C.. Improved quantitative capillary refill time measurement: a melanin-insensitive approach in search of robust algorithms. NOVEL OPTICAL SYSTEMS, METHODS, AND APPLICATIONS XXVII, v. 13130, p. 4-pg., 2024-01-01. (18/16939-8, 22/16344-0)

VICENTE, THIAGO T.; ARSALANI, SAEIDEH; QUIEL, MATEUS S.; FERNANDES, GUILHERME S. P.; DA SILVA, KETERYNE R.; FUKADA, SANDRA Y.; GUALDI, ALEXANDRE J.; GUIDELLI, EDER J.; BAFFA, OSWALDO; CARNEIRO, ANTONIO A. O.; et al. Improving the Theranostic Potential of Magnetic Nanoparticles by Coating with Natural Rubber Latex for Ultrasound, Photoacoustic Imaging, and Magnetic Hyperthermia: An In Vitro Study. PHARMACEUTICS, v. 16, n. 11, p. 22-pg., 2024-11-01. (18/16939-8, 21/06728-2, 13/18854-6, 17/14482-8, 13/07699-0)

HUBER, CHRISTIAN MARINUS; PAVAN, THEO Z.; ULLMANN, INGRID; HEIM, CHRISTIAN; RUPITSCH, STEFAN J.; VOSSIEK, MARTIN; ALEXIOU, CHRISTOPH; ERMERT, HELMUT; LYER, STEFAN. A Review on Ultrasound-based Methods to Image the Distribution of Magnetic Nanoparticles in Biomedical Applications. ULTRASOUND IN MEDICINE AND BIOLOGY, v. 51, n. 2, p. 25-pg., 2024-12-19. (21/06728-2, 18/16939-8)